ID   DCA10_DANRE             Reviewed;         508 AA.
AC   Q6NWH1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DDB1- and CUL4-associated factor 10;
DE   AltName: Full=WD repeat-containing protein 32;
GN   Name=dcaf10; Synonyms=wdr32; ORFNames=zgc:85718;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF10 family. {ECO:0000305}.
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DR   EMBL; BC067591; AAH67591.2; -; mRNA.
DR   RefSeq; NP_998111.2; NM_212946.1.
DR   AlphaFoldDB; Q6NWH1; -.
DR   STRING; 7955.ENSDARP00000047739; -.
DR   PaxDb; Q6NWH1; -.
DR   PRIDE; Q6NWH1; -.
DR   Ensembl; ENSDART00000047740; ENSDARP00000047739; ENSDARG00000029600.
DR   Ensembl; ENSDART00000183067; ENSDARP00000152086; ENSDARG00000110405.
DR   GeneID; 405882; -.
DR   KEGG; dre:405882; -.
DR   CTD; 405882; -.
DR   ZFIN; ZDB-GENE-040426-2314; wdr32.
DR   eggNOG; KOG0264; Eukaryota.
DR   eggNOG; KOG4155; Eukaryota.
DR   GeneTree; ENSGT00390000012666; -.
DR   HOGENOM; CLU_028919_2_0_1; -.
DR   InParanoid; Q6NWH1; -.
DR   OMA; EFQEGTP; -.
DR   OrthoDB; 1068414at2759; -.
DR   PhylomeDB; Q6NWH1; -.
DR   TreeFam; TF323434; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q6NWH1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000029600; Expressed in early embryo and 26 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR039085; DCA10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14588; PTHR14588; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..508
FT                   /note="DDB1- and CUL4-associated factor 10"
FT                   /id="PRO_0000306835"
FT   REPEAT          126..165
FT                   /note="WD 1"
FT   REPEAT          169..207
FT                   /note="WD 2"
FT   REPEAT          211..250
FT                   /note="WD 3"
FT   REPEAT          256..295
FT                   /note="WD 4"
FT   REPEAT          356..396
FT                   /note="WD 5"
FT   REPEAT          419..457
FT                   /note="WD 6"
FT   REPEAT          475..508
FT                   /note="WD 7"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..32
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  56675 MW;  54850387517E7381 CRC64;
     MSSGHPSDNE EPRADLLREE EEEEEEEEDS DEDRGSTRPA SPQATRECAG TQGSSRPEVT
     ADGGTGSASG SGCRGSGACD SLFSWICRRK IRRGPYVDPA RDHFRTMTRL YSSMSPAADS
     VNLSTQTHGA VFNLEYSPDG SVLTVACEQT EVLLFDPVSS RHIKTLVEAH EDCVNNIRFL
     DNRLFATCSD DTTIALWDLR KLNSKVCSLH GHASWVKNIE YDTHTRLLVT SGFDGNVITW
     DTNRFTEDGC PHKKFFHTRY LMRMRLTPDC SKMLISTSSG YLLILHDLDL TQSLEVGSYR
     ILRARRPPLS TEGSSAGSRS GGPRHTIDNK NHPHREGLSP RNSLEVLTPE IPGERDRGNC
     ITSLQLHPKG WATLLRCSSN MDDQEWTCVY EFQEGAPPRP PVSPRCSLRL THYIEEANVG
     RGYIKELCFS PDGRLICSPY GYGVRLLAFD ENCAELVDCM PVRTAQLREV RSIYSHSDVV
     LTSKFSPTHC QFASGCLSGR VALYQPHF