DCA10_DROME
ID DCA10_DROME Reviewed; 621 AA.
AC Q9VAT2; Q960M2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=DDB1- and CUL4-associated factor 10 homolog;
DE AltName: Full=WD repeat-containing protein 32 homolog;
GN ORFNames=CG1523;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-494 AND SER-497, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93410.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF56817.1; -; Genomic_DNA.
DR EMBL; AY051986; AAK93410.1; ALT_FRAME; mRNA.
DR RefSeq; NP_651635.2; NM_143378.4.
DR AlphaFoldDB; Q9VAT2; -.
DR SMR; Q9VAT2; -.
DR BioGRID; 68276; 2.
DR IntAct; Q9VAT2; 2.
DR STRING; 7227.FBpp0084724; -.
DR iPTMnet; Q9VAT2; -.
DR PaxDb; Q9VAT2; -.
DR PRIDE; Q9VAT2; -.
DR EnsemblMetazoa; FBtr0085355; FBpp0084724; FBgn0039601.
DR GeneID; 43400; -.
DR KEGG; dme:Dmel_CG1523; -.
DR UCSC; CG1523-RA; d. melanogaster.
DR FlyBase; FBgn0039601; CG1523.
DR VEuPathDB; VectorBase:FBgn0039601; -.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00390000012666; -.
DR HOGENOM; CLU_028919_1_0_1; -.
DR InParanoid; Q9VAT2; -.
DR OMA; FPEQNDA; -.
DR OrthoDB; 1068414at2759; -.
DR PhylomeDB; Q9VAT2; -.
DR Reactome; R-DME-8951664; Neddylation.
DR BioGRID-ORCS; 43400; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG1523; fly.
DR GenomeRNAi; 43400; -.
DR PRO; PR:Q9VAT2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039601; Expressed in eye disc (Drosophila) and 24 other tissues.
DR Genevisible; Q9VAT2; DM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR039085; DCA10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14588; PTHR14588; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..621
FT /note="DDB1- and CUL4-associated factor 10 homolog"
FT /id="PRO_0000306838"
FT REPEAT 46..85
FT /note="WD 1"
FT REPEAT 89..127
FT /note="WD 2"
FT REPEAT 131..170
FT /note="WD 3"
FT REPEAT 176..215
FT /note="WD 4"
FT REPEAT 588..621
FT /note="WD 5"
FT REGION 305..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 494
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 497
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 470
FT /note="S -> N (in Ref. 3; AAK93410)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 621 AA; 69566 MW; 011004C3260857E9 CRC64;
MERYLSRRES GFHIHRSDDN SLMRRIYSSM NMFNSYHANC WPTDAGRTGA IFNLEFNADG
NVVVAATERK CVLVFDAITQ KEIFKVPDAH TDSVNCIKFF DERLFATGSD DFTVALWDLR
NMKQKLRVLH GHSNWVKNIE YSSKDKLLVS SGFDGSIFTW DINSQTEQGL ISQRVFHASG
LMRCRISPTG DKLVLCTSGG YIMIIHHLDL TTLHKDLCGF RPGIYRLMQL GEQYIPQAAK
YDHVFSKRQK KNRVELVTDF PENNDAEMIM ALQIHPHCCC MLTRNVSCDE QSEWTCIHDI
NEEPVRSEDE QDEVEPQPKR KRVSTTLASR SSLNESQDQD TVGLTPRQAR RPLRVSSVQV
FQLDNSGAGR GASDNPSVLT RSDSFIPDIW AAEVTVQERA IRQNRARVSN NHVSGYNFVY
AISSGVLPLR QLGANSLMGS STSPRPLTTP PPTESNQSSS SSSSSSSSSS SSSSSNNSDT
TVRLEIGNRL RLRSFNSPVT TPTFKENGHS ILVNAKKLLY YAAETNTKPG FIKEPGFSAD
GRVVCSPYGN GVRLFGYSED CCDYPKCQAF EEVKSKPRKL VELAKITEHQ DVVLCAKFSP
REPLLVTGCN GGEVTWYRPN L
