ID   DCA10_XENLA             Reviewed;         457 AA.
AC   Q8AVS9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DDB1- and CUL4-associated factor 10;
DE   AltName: Full=WD repeat-containing protein 32;
GN   Name=dcaf10; Synonyms=wdr32;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF10 family. {ECO:0000305}.
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DR   EMBL; BC041284; AAH41284.1; -; mRNA.
DR   RefSeq; NP_001079393.1; NM_001085924.1.
DR   AlphaFoldDB; Q8AVS9; -.
DR   SMR; Q8AVS9; -.
DR   DNASU; 379080; -.
DR   GeneID; 379080; -.
DR   KEGG; xla:379080; -.
DR   CTD; 379080; -.
DR   Xenbase; XB-GENE-967162; dcaf10.L.
DR   OrthoDB; 1068414at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379080; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR039085; DCA10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14588; PTHR14588; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..457
FT                   /note="DDB1- and CUL4-associated factor 10"
FT                   /id="PRO_0000306836"
FT   REPEAT          65..104
FT                   /note="WD 1"
FT   REPEAT          108..146
FT                   /note="WD 2"
FT   REPEAT          150..189
FT                   /note="WD 3"
FT   REPEAT          195..234
FT                   /note="WD 4"
FT   REPEAT          306..346
FT                   /note="WD 5"
FT   REPEAT          368..406
FT                   /note="WD 6"
FT   REPEAT          424..457
FT                   /note="WD 7"
FT   REGION          246..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  51022 MW;  EE44FE225DD0039B CRC64;
     MEGCTKDGAA VQSSGASTAG SIFWWLKDRS LGRGICVDPA RDNFRTMTSL YSSIHPADSV
     NLSTRTHGAV FNLEYSPDGS VLTLACEQTE VLLFDPLSSK HIKTLSEAHE DCVNNIRFLD
     NRMFATCSDD TTIALWDLRK LNSKACTLHG HTSWVKNIEY DKNTRLLVTS GFDGNVIIWD
     TNRCTEDGCP HKKFFHTRFL MRMRLTPDCS KMLISTSSGY LLILHELDLT KSLEVGSYPI
     LRARRTASTS DMTSTSSETR PSSSPCHNSD SGPLFEKHMS RSSQREGTSP RNSLEVLTPE
     VPGERDRGNC ITSLQLHPKG WATLLRCSSN TDDQEWTCVY EFQEGTPVRQ VSPRCSLRLT
     HYIEEANVGR GYIKELCFSP DGRMIASPHG YGIRLLGFDS QCKELVDCLP KEAGTLQEIR
     SLYSHKDVVL TTKFSPTHCQ IASGCLSGRV SLYQPKF