ID   DCA10_XENTR             Reviewed;         457 AA.
AC   Q5FW06;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DDB1- and CUL4-associated factor 10;
DE   AltName: Full=WD repeat-containing protein 32;
GN   Name=dcaf10; Synonyms=wdr32; ORFNames=TEgg067n05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH89677.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR762027; CAJ81491.1; -; mRNA.
DR   EMBL; BC089677; AAH89677.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001015742.2; NM_001015742.2.
DR   AlphaFoldDB; Q5FW06; -.
DR   STRING; 8364.ENSXETP00000004775; -.
DR   PaxDb; Q5FW06; -.
DR   DNASU; 548459; -.
DR   Ensembl; ENSXETT00000004775; ENSXETP00000004775; ENSXETG00000002243.
DR   GeneID; 548459; -.
DR   KEGG; xtr:548459; -.
DR   CTD; 79269; -.
DR   Xenbase; XB-GENE-967155; dcaf10.
DR   eggNOG; KOG0264; Eukaryota.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_028919_2_0_1; -.
DR   InParanoid; Q5FW06; -.
DR   OMA; NISTQTH; -.
DR   OrthoDB; 1068414at2759; -.
DR   PhylomeDB; Q5FW06; -.
DR   TreeFam; TF323434; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002243; Expressed in skeletal muscle tissue and 15 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR039085; DCA10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14588; PTHR14588; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..457
FT                   /note="DDB1- and CUL4-associated factor 10"
FT                   /id="PRO_0000306837"
FT   REPEAT          65..104
FT                   /note="WD 1"
FT   REPEAT          108..146
FT                   /note="WD 2"
FT   REPEAT          150..189
FT                   /note="WD 3"
FT   REPEAT          195..234
FT                   /note="WD 4"
FT   REPEAT          306..346
FT                   /note="WD 5"
FT   REPEAT          368..406
FT                   /note="WD 6"
FT   REPEAT          424..457
FT                   /note="WD 7"
FT   REGION          246..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  50862 MW;  5397618FB2E63E88 CRC64;
     MEGGTNDGAA VPGNGAGTAG SIFWWLKNRC LGRGLCVDPA RDNFRTMTSL YSSIHPADSV
     NLSTRTHGAV FNLEYSPDGS VLTVACEQTE VLLFDPVSSK HIKTLSEAHE DCVNNIRFLD
     NRMFATCSDD TTIALWDLRK LNSKVCTLHG HTSWVKNIEY DTNTRLLVTS GFDGNVIIWD
     TNRCTEDGCP HKKFFHTRFL MRMRLTPDCS KMLISTSSGY LLILHELDLT KSLEVGSYPI
     LRARRTASTS DMTSTSSDTR PSSSPCHNSD LGPLFEKHMS RSSQREGASP RNSLEVLTPE
     VPGERDRGNC ITSLQLHPKG WATLLRCSSN TDDQEWTCVY EFQEGAPVRQ VSPRCSLRLT
     HYIEEANVGR GYIKELCFSP DGRMIASPYA YGIRLLGFDS QCKELVDCLP KEAGTLQVIR
     SLYSHKDVVL TTKFSPTHCQ IASGCLSGRV TLYQPKF