DCA11_BOVIN
ID DCA11_BOVIN Reviewed; 546 AA.
AC Q5E9I8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=DDB1- and CUL4-associated factor 11;
DE AltName: Full=WD repeat-containing protein 23;
GN Name=DCAF11; Synonyms=WDR23;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
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DR EMBL; BT020932; AAX08949.1; -; mRNA.
DR RefSeq; NP_001014954.1; NM_001014954.1.
DR AlphaFoldDB; Q5E9I8; -.
DR SMR; Q5E9I8; -.
DR STRING; 9913.ENSBTAP00000028515; -.
DR PaxDb; Q5E9I8; -.
DR PRIDE; Q5E9I8; -.
DR GeneID; 539433; -.
DR KEGG; bta:539433; -.
DR CTD; 80344; -.
DR eggNOG; KOG0266; Eukaryota.
DR InParanoid; Q5E9I8; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR017399; DCAF11/LEC14B.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1..546
FT /note="DDB1- and CUL4-associated factor 11"
FT /id="PRO_0000244454"
FT REPEAT 170..210
FT /note="WD 1"
FT REPEAT 216..258
FT /note="WD 2"
FT REPEAT 263..302
FT /note="WD 3"
FT REPEAT 305..345
FT /note="WD 4"
FT REPEAT 353..392
FT /note="WD 5"
FT REPEAT 435..480
FT /note="WD 6"
FT REPEAT 481..520
FT /note="WD 7"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91VU6"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91VU6"
SQ SEQUENCE 546 AA; 61595 MW; 63B5311F2F150820 CRC64;
MGSRNSSSAG TGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
GGAANLQLIQ ALSDSEEEHD SAWDGRLGDR YNPPVDATPD TRELECSEIK TQVELATGRL
GLRRAARELS FPQMLHQRER GLCHQGSFSL GERSRVMSHF LPNDLGFTDT YSQKAFCGIY
SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD
YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
LQIESHEDDV NAVAFADVSS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL
KLPGDSSLMT YRGHGVLHTL IRCRFSPTHS TGQQFIYSGC STGKVVVYDL LSGHVVKKLT
THKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEEHPS TPAPMSHPST
AFSSPQ
