ID   DCA11_CAEBR             Reviewed;         554 AA.
AC   A8XEN7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=DDB1- and CUL4-associated factor 11 homolog;
DE   AltName: Full=WD repeat-containing protein 23 {ECO:0000250|UniProtKB:P90794};
GN   Name=wdr-23; ORFNames=CBG11954;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Involved in regulation of lifespan. Required for dopaminergic
CC       CEP neuron degeneration in response to Mn(2+).
CC       {ECO:0000250|UniProtKB:P90794}.
CC   -!- SIMILARITY: Belongs to the WD repeat LEC14B family. {ECO:0000255}.
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DR   EMBL; HE601540; CAP31005.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XEN7; -.
DR   SMR; A8XEN7; -.
DR   STRING; 6238.CBG11954; -.
DR   WormBase; CBG11954a; CBP39249; WBGene00032973; Cbr-wdr-23.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_014280_3_1_1; -.
DR   InParanoid; A8XEN7; -.
DR   OMA; FDVDDMG; -.
DR   OrthoDB; 1219799at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR017399; DCAF11/LEC14B.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..554
FT                   /note="DDB1- and CUL4-associated factor 11 homolog"
FT                   /id="PRO_0000358603"
FT   REPEAT          245..284
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          288..328
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          336..375
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          414..458
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          461..500
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REGION          24..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  62976 MW;  1965CD6752F372AD CRC64;
     MYAKKFTGSD PQTVRTAAEI VALQRMKNRN DSDTDFSDDD EETSGGCPKM TPQEEQRMFE
     REQQIAFSGR CTIGDPESCH QLRTDINHRC GPRPSTSSNA TWNILNRDVQ RRNGPVMTSA
     SRAHLLNTHL PNKKRRVDQL RTKNFCAQYI QNGRKMVVSS QGERENSFLS TKSGKIEISL
     PILSMQRTPC GPLQLVDLDT AVNQQGDLIS YCTWKDAVYI GRMEQEDNQN ITWFPIDWHG
     EHAVQNQCAV FCVRFSDDSE QIVCGTSEYS IHVFDVEQRR RIRTIVNAHE DDVNSVCFAD
     YGSNLIYSAG DDGLVKVWDK RAWSDGDVIP VGVFAGHRDG VTYVDSRQDE RYLLSNSKDQ
     TIKVWDLRKF SCQGGVEATR ACVQSQHWDY RWQPAPPGLC QPVQGDTSVM TLRGHSVLHT
     LVRAKFSPEN TGRRFIYTGC ARGEIVVYDI VTGTVSRRLK GHQAVVRECD WHPQENEIVS
     TSWDGVTTVW TWDERAEGVI APYDHPNIHQ FGDEDSCDEL YQPIKKPQRK LRKPISARNA
     KCPTTSSEPD DFQI