DCA11_CAEEL
ID DCA11_CAEEL Reviewed; 571 AA.
AC P90794; Q9U3K9;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=DDB1- and CUL4-associated factor 11 homolog;
DE AltName: Full=WD repeat-containing protein 23;
GN Name=wdr-23 {ECO:0000312|WormBase:D2030.9a};
GN ORFNames=D2030.9 {ECO:0000312|WormBase:D2030.9a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17411345; DOI=10.1371/journal.pgen.0030056;
RA Curran S.P., Ruvkun G.;
RT "Lifespan regulation by evolutionarily conserved genes essential for
RT viability.";
RL PLoS Genet. 3:E56-E56(2007).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23721876; DOI=10.1016/j.neuro.2013.05.014;
RA Settivari R., VanDuyn N., LeVora J., Nass R.;
RT "The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1
RT inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of
RT manganism.";
RL NeuroToxicology 38:51-60(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=31043480; DOI=10.1074/jbc.ra118.004426;
RA Ipson B.R., Green R.A., Wilson J.T., Watson J.N., Faull K.F., Fisher A.L.;
RT "Tyrosine aminotransferase is involved in the oxidative stress response by
RT metabolizing meta-tyrosine in Caenorhabditis elegans.";
RL J. Biol. Chem. 294:9536-9554(2019).
CC -!- FUNCTION: Involved in regulation of lifespan (PubMed:17411345).
CC Required for dopaminergic CEP neuron degeneration in response to Mn(2+)
CC (PubMed:23721876). Inhibits the skn-1-mediated up-regulation of tatn-1
CC (PubMed:31043480). {ECO:0000269|PubMed:17411345,
CC ECO:0000269|PubMed:23721876, ECO:0000269|PubMed:31043480}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:D2030.9a};
CC IsoId=P90794-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:D2030.9b};
CC IsoId=P90794-2; Sequence=VSP_036072, VSP_036073;
CC -!- DISRUPTION PHENOTYPE: Increased lifespan (PubMed:17411345). RNAi-
CC mediated knockdown significantly prevents Mn(2+)-induced dopaminergic
CC CEP neuron degeneration (PubMed:23721876). RNAi-mediated knockdown
CC increases tatn-1 expression and enzymatic activity (PubMed:31043480).
CC {ECO:0000269|PubMed:17411345, ECO:0000269|PubMed:23721876,
CC ECO:0000269|PubMed:31043480}.
CC -!- SIMILARITY: Belongs to the WD repeat LEC14B family. {ECO:0000305}.
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DR EMBL; BX284601; CAA98121.1; -; Genomic_DNA.
DR EMBL; BX284601; CAB54209.1; -; Genomic_DNA.
DR PIR; T20359; T20359.
DR PIR; T20360; T20360.
DR RefSeq; NP_492124.1; NM_059723.4. [P90794-1]
DR RefSeq; NP_492125.1; NM_059724.3. [P90794-2]
DR AlphaFoldDB; P90794; -.
DR SMR; P90794; -.
DR BioGRID; 37960; 6.
DR DIP; DIP-26027N; -.
DR STRING; 6239.D2030.9a.1; -.
DR PaxDb; P90794; -.
DR EnsemblMetazoa; D2030.9a.1; D2030.9a.1; WBGene00008419. [P90794-1]
DR EnsemblMetazoa; D2030.9a.2; D2030.9a.2; WBGene00008419. [P90794-1]
DR EnsemblMetazoa; D2030.9b.1; D2030.9b.1; WBGene00008419. [P90794-2]
DR GeneID; 172518; -.
DR KEGG; cel:CELE_D2030.9; -.
DR UCSC; D2030.9a; c. elegans.
DR CTD; 172518; -.
DR WormBase; D2030.9a; CE09086; WBGene00008419; wdr-23. [P90794-1]
DR WormBase; D2030.9b; CE23620; WBGene00008419; wdr-23. [P90794-2]
DR eggNOG; KOG0266; Eukaryota.
DR InParanoid; P90794; -.
DR OMA; FDVDDMG; -.
DR OrthoDB; 1219799at2759; -.
DR PhylomeDB; P90794; -.
DR Reactome; R-CEL-8951664; Neddylation.
DR PRO; PR:P90794; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00008419; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; P90794; baseline and differential.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:WormBase.
DR GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0055120; C:striated muscle dense body; IDA:WormBase.
DR GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
DR GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:1905803; P:negative regulation of cellular response to manganese ion; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:1901216; P:positive regulation of neuron death; IMP:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:WormBase.
DR GO; GO:0080135; P:regulation of cellular response to stress; IMP:WormBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR017399; DCAF11/LEC14B.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..571
FT /note="DDB1- and CUL4-associated factor 11 homolog"
FT /id="PRO_0000051510"
FT REPEAT 162..201
FT /note="WD 1"
FT REPEAT 266..305
FT /note="WD 2"
FT REPEAT 309..349
FT /note="WD 3"
FT REPEAT 357..396
FT /note="WD 4"
FT REPEAT 435..479
FT /note="WD 5"
FT REPEAT 482..521
FT /note="WD 6"
FT REGION 51..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..41
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_036072"
FT VAR_SEQ 42..54
FT /note="TAAEIVAHQRMKP -> MPYKRHSSSNLKR (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_036073"
SQ SEQUENCE 571 AA; 65171 MW; 521932753C6F8FC4 CRC64;
MGNWITSTFL RFDLFQRHQP NRFLEYTRVQ HSNQSPAYSV RTAAEIVAHQ RMKPNHSNDS
DTDFSSDDEG CPKMTPHEEQ QMFEREQHIA FSGRCHIGDP ESCTQLRNEI NSRCGPRPST
SNNMEFILNR DLQKRGTSIS NPRTVARVLN SHLPNQKRRV DRVATKSFCT QYIQNGTKIV
VASQDEKIRF YQRNPDKSKY RSKYMKSDEL RVDQCGWSIL DTAISLNGDL IAYGTWKDAV
FVGKLDFTER QNITWFPIDL NGEPGRDHCA VFCVKFSDSS EQIVCGTSQY SIHVFDVEQR
RRIRTIVNAH EDDVNSVCFA DLGSNLIYSA GDDGLVKVWD KRAWSDGDVE PVGVFAGHRD
GVTHVDSRQD ERYLLSNSKD QTIKVWDLRK FSNMSGVEAT RACVQSQHWD YRWQPAPPGL
CQPVAGDTSV MTLRGHSVLH TLVRANFSPE STGRRYIYTG CARGEVVVYD IMSGTVSRRL
KGHTAVVREC DWHPTENEIV SSAWDGVTTV WTWDERQEGV IAPYDHPNIS QFGDEDSCDE
LFQPVKKQCR RQRKTMSSRG HPCSSSSISQ N
