DCA11_HUMAN
ID DCA11_HUMAN Reviewed; 546 AA.
AC Q8TEB1; B3KQ83; D3DS56; Q5D039; Q86U00; Q86U39; Q8NDN2; Q9H2J0; Q9H3A3;
AC Q9H5C9;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=DDB1- and CUL4-associated factor 11;
DE AltName: Full=WD repeat-containing protein 23;
GN Name=DCAF11; Synonyms=WDR23; ORFNames=GL014, PRO2389;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1), AND VARIANT HIS-207.
RC TISSUE=Liver;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hepatoma, Lung, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Fetal brain, and Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT HIS-207.
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-546, AND VARIANT HIS-207.
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W.,
RA Gao F., Liu M., He F.;
RT "Functional prediction of the coding sequences of 75 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-546.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP FUNCTION, INTERACTION WITH DDB1 AND CUL4A, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16949367; DOI=10.1016/j.molcel.2006.08.010;
RA Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C.;
RT "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is
RT required for S phase destruction of the replication factor Cdt1.";
RL Mol. Cell 23:709-721(2006).
RN [10]
RP FUNCTION.
RX PubMed=16964240; DOI=10.1038/nature05175;
RA Angers S., Li T., Yi X., MacCoss M.J., Moon R.T., Zheng N.;
RT "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase
RT machinery.";
RL Nature 443:590-593(2006).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,
CC ECO:0000269|PubMed:16964240}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000269|PubMed:16949367}.
CC -!- INTERACTION:
CC Q8TEB1; O95994: AGR2; NbExp=3; IntAct=EBI-2213388, EBI-712648;
CC Q8TEB1; Q16531: DDB1; NbExp=2; IntAct=EBI-2213388, EBI-350322;
CC Q8TEB1; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-2213388, EBI-10261098;
CC Q8TEB1; Q15293: RCN1; NbExp=5; IntAct=EBI-2213388, EBI-948278;
CC Q8TEB1; P19237: TNNI1; NbExp=3; IntAct=EBI-2213388, EBI-746692;
CC Q8TEB1; P48788: TNNI2; NbExp=3; IntAct=EBI-2213388, EBI-7746394;
CC Q8TEB1; P12504: vif; Xeno; NbExp=3; IntAct=EBI-2213388, EBI-779991;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TEB1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TEB1-2; Sequence=VSP_008424;
CC Name=3;
CC IsoId=Q8TEB1-3; Sequence=VSP_008423;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG35498.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAG44727.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF267858; AAG44727.1; ALT_FRAME; mRNA.
DR EMBL; AK027223; BAB15698.1; ALT_INIT; mRNA.
DR EMBL; AK057636; BAG51945.1; -; mRNA.
DR EMBL; AK074296; BAB85041.1; -; mRNA.
DR EMBL; BX161405; CAD61885.1; -; mRNA.
DR EMBL; BX247970; CAD62308.1; -; mRNA.
DR EMBL; AL136295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66110.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66111.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66112.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66113.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66114.1; -; Genomic_DNA.
DR EMBL; BC008858; AAH08858.2; -; mRNA.
DR EMBL; BC067132; AAH67132.1; -; mRNA.
DR EMBL; AF130070; AAG35498.1; ALT_INIT; mRNA.
DR EMBL; AL833831; CAD38691.1; -; mRNA.
DR CCDS; CCDS41929.1; -. [Q8TEB1-2]
DR CCDS; CCDS9610.1; -. [Q8TEB1-1]
DR RefSeq; NP_001156956.1; NM_001163484.1. [Q8TEB1-1]
DR RefSeq; NP_079506.3; NM_025230.4. [Q8TEB1-1]
DR RefSeq; NP_852002.1; NM_181357.2. [Q8TEB1-2]
DR AlphaFoldDB; Q8TEB1; -.
DR SMR; Q8TEB1; -.
DR BioGRID; 123251; 97.
DR IntAct; Q8TEB1; 47.
DR MINT; Q8TEB1; -.
DR STRING; 9606.ENSP00000415556; -.
DR iPTMnet; Q8TEB1; -.
DR PhosphoSitePlus; Q8TEB1; -.
DR BioMuta; DCAF11; -.
DR DMDM; 37538034; -.
DR EPD; Q8TEB1; -.
DR jPOST; Q8TEB1; -.
DR MassIVE; Q8TEB1; -.
DR MaxQB; Q8TEB1; -.
DR PaxDb; Q8TEB1; -.
DR PeptideAtlas; Q8TEB1; -.
DR PRIDE; Q8TEB1; -.
DR ProteomicsDB; 74434; -. [Q8TEB1-1]
DR ProteomicsDB; 74435; -. [Q8TEB1-2]
DR ProteomicsDB; 74436; -. [Q8TEB1-3]
DR Antibodypedia; 22622; 88 antibodies from 19 providers.
DR DNASU; 80344; -.
DR Ensembl; ENST00000396936.5; ENSP00000380142.1; ENSG00000100897.18. [Q8TEB1-3]
DR Ensembl; ENST00000396941.8; ENSP00000380146.4; ENSG00000100897.18. [Q8TEB1-2]
DR Ensembl; ENST00000446197.8; ENSP00000415556.4; ENSG00000100897.18. [Q8TEB1-1]
DR Ensembl; ENST00000559115.5; ENSP00000452898.1; ENSG00000100897.18. [Q8TEB1-1]
DR Ensembl; ENST00000642239.1; ENSP00000494282.1; ENSG00000284796.3. [Q8TEB1-1]
DR Ensembl; ENST00000644566.1; ENSP00000493711.1; ENSG00000284796.3. [Q8TEB1-2]
DR Ensembl; ENST00000646524.1; ENSP00000495415.1; ENSG00000284796.3. [Q8TEB1-3]
DR Ensembl; ENST00000646568.3; ENSP00000495416.1; ENSG00000284796.3. [Q8TEB1-1]
DR GeneID; 80344; -.
DR KEGG; hsa:80344; -.
DR MANE-Select; ENST00000446197.8; ENSP00000415556.4; NM_025230.5; NP_079506.3.
DR UCSC; uc001wlv.4; human. [Q8TEB1-1]
DR CTD; 80344; -.
DR DisGeNET; 80344; -.
DR GeneCards; DCAF11; -.
DR HGNC; HGNC:20258; DCAF11.
DR HPA; ENSG00000100897; Low tissue specificity.
DR MIM; 613317; gene.
DR neXtProt; NX_Q8TEB1; -.
DR OpenTargets; ENSG00000100897; -.
DR PharmGKB; PA165478701; -.
DR VEuPathDB; HostDB:ENSG00000100897; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00720000108873; -.
DR HOGENOM; CLU_014280_3_1_1; -.
DR InParanoid; Q8TEB1; -.
DR OMA; MMSHFLP; -.
DR PhylomeDB; Q8TEB1; -.
DR TreeFam; TF314126; -.
DR PathwayCommons; Q8TEB1; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR SignaLink; Q8TEB1; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 80344; 10 hits in 1117 CRISPR screens.
DR ChiTaRS; DCAF11; human.
DR GenomeRNAi; 80344; -.
DR Pharos; Q8TEB1; Tbio.
DR PRO; PR:Q8TEB1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8TEB1; protein.
DR Bgee; ENSG00000100897; Expressed in right lobe of liver and 105 other tissues.
DR ExpressionAtlas; Q8TEB1; baseline and differential.
DR Genevisible; Q8TEB1; HS.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR017399; DCAF11/LEC14B.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..546
FT /note="DDB1- and CUL4-associated factor 11"
FT /id="PRO_0000051371"
FT REPEAT 170..210
FT /note="WD 1"
FT REPEAT 216..258
FT /note="WD 2"
FT REPEAT 263..302
FT /note="WD 3"
FT REPEAT 305..345
FT /note="WD 4"
FT REPEAT 353..392
FT /note="WD 5"
FT REPEAT 435..480
FT /note="WD 6"
FT REPEAT 481..520
FT /note="WD 7"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91VU6"
FT VAR_SEQ 1..159
FT /note="MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRR
FT GQVRLVQGGGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKT
FT QVELATGQLGLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISH -> MTELGMV
FT VLGIDTTHLWMLPLTPGSWNSMRSRHKWNWPQGSWGLGGPPRSTAFLECCTS (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_008423"
FT VAR_SEQ 45..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
FT /id="VSP_008424"
FT VARIANT 207
FT /note="R -> H (in dbSNP:rs3825584)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.7"
FT /id="VAR_020121"
FT CONFLICT 125
FT /note="A -> P (in Ref. 7)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="L -> S (in Ref. 7; AAG35498)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="I -> KS (in Ref. 6; AAH08858)"
FT /evidence="ECO:0000305"
FT MOD_RES Q8TEB1-2:49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
SQ SEQUENCE 546 AA; 61670 MW; 274A98A59059815D CRC64;
MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL
GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY
SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD
YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL
KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST
PFSSPQ
