DCA11_MOUSE
ID DCA11_MOUSE Reviewed; 549 AA.
AC Q91VU6; Q3U836; Q8JZV8;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=DDB1- and CUL4-associated factor 11;
DE AltName: Full=WD repeat-containing protein 23;
GN Name=Dcaf11; Synonyms=D14Ucla1, Wdr23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-75, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91VU6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91VU6-2; Sequence=VSP_008425, VSP_008426;
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DR EMBL; AK033540; BAC28348.1; -; mRNA.
DR EMBL; AK152395; BAE31183.1; -; mRNA.
DR EMBL; BC008545; AAH08545.1; -; mRNA.
DR EMBL; BC037001; AAH37001.1; -; mRNA.
DR CCDS; CCDS27115.1; -. [Q91VU6-1]
DR RefSeq; NP_001185938.1; NM_001199009.1. [Q91VU6-1]
DR RefSeq; NP_598495.1; NM_133734.3. [Q91VU6-1]
DR RefSeq; XP_006519144.1; XM_006519081.3. [Q91VU6-1]
DR RefSeq; XP_006519146.1; XM_006519083.3. [Q91VU6-1]
DR RefSeq; XP_006519147.1; XM_006519084.3. [Q91VU6-1]
DR RefSeq; XP_006519148.1; XM_006519085.3. [Q91VU6-1]
DR RefSeq; XP_006519149.1; XM_006519086.3. [Q91VU6-1]
DR RefSeq; XP_006519150.1; XM_006519087.3. [Q91VU6-2]
DR RefSeq; XP_006519151.1; XM_006519088.3. [Q91VU6-2]
DR RefSeq; XP_006519152.1; XM_006519089.2.
DR RefSeq; XP_006519153.1; XM_006519090.3. [Q91VU6-2]
DR RefSeq; XP_006519154.1; XM_006519091.3. [Q91VU6-2]
DR AlphaFoldDB; Q91VU6; -.
DR SMR; Q91VU6; -.
DR BioGRID; 205826; 5.
DR STRING; 10090.ENSMUSP00000072344; -.
DR iPTMnet; Q91VU6; -.
DR PhosphoSitePlus; Q91VU6; -.
DR EPD; Q91VU6; -.
DR jPOST; Q91VU6; -.
DR MaxQB; Q91VU6; -.
DR PaxDb; Q91VU6; -.
DR PRIDE; Q91VU6; -.
DR ProteomicsDB; 277958; -. [Q91VU6-1]
DR ProteomicsDB; 277959; -. [Q91VU6-2]
DR DNASU; 28199; -.
DR Ensembl; ENSMUST00000072530; ENSMUSP00000072344; ENSMUSG00000022214. [Q91VU6-1]
DR Ensembl; ENSMUST00000117236; ENSMUSP00000113014; ENSMUSG00000022214. [Q91VU6-1]
DR Ensembl; ENSMUST00000121622; ENSMUSP00000113202; ENSMUSG00000022214. [Q91VU6-1]
DR Ensembl; ENSMUST00000128490; ENSMUSP00000114211; ENSMUSG00000022214. [Q91VU6-1]
DR GeneID; 28199; -.
DR KEGG; mmu:28199; -.
DR UCSC; uc007tyz.2; mouse. [Q91VU6-1]
DR CTD; 80344; -.
DR MGI; MGI:90168; Dcaf11.
DR VEuPathDB; HostDB:ENSMUSG00000022214; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00720000108873; -.
DR HOGENOM; CLU_014280_3_1_1; -.
DR InParanoid; Q91VU6; -.
DR OMA; MMSHFLP; -.
DR OrthoDB; 1219799at2759; -.
DR PhylomeDB; Q91VU6; -.
DR TreeFam; TF314126; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 28199; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Dcaf11; mouse.
DR PRO; PR:Q91VU6; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q91VU6; protein.
DR Bgee; ENSMUSG00000022214; Expressed in left lobe of liver and 252 other tissues.
DR ExpressionAtlas; Q91VU6; baseline and differential.
DR Genevisible; Q91VU6; MM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR017399; DCAF11/LEC14B.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..549
FT /note="DDB1- and CUL4-associated factor 11"
FT /id="PRO_0000051372"
FT REPEAT 170..210
FT /note="WD 1"
FT REPEAT 216..258
FT /note="WD 2"
FT REPEAT 263..302
FT /note="WD 3"
FT REPEAT 305..345
FT /note="WD 4"
FT REPEAT 353..392
FT /note="WD 5"
FT REPEAT 435..480
FT /note="WD 6"
FT REPEAT 481..520
FT /note="WD 7"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..44
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_008425"
FT VAR_SEQ 45..51
FT /note="VLAYLLR -> MKMWIWP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_008426"
SQ SEQUENCE 549 AA; 61992 MW; 0ACECBEC90887352 CRC64;
MGSRNSSSAG SGSLEPSEGL SRRGTGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
RGAANLQLIQ ALSDSEEEHD SAWDGRLGDR YNPPVDATPD TRELEYNEIK TQVGLATGRL
GLRRTALQQS FPQMLHQRER GLCHRGSFSL GEQSRVMSHF LPNDLSFTDT YSQKAFCGIY
SKDGQIFMSA CQDQTIRLYD CRYGRFHKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD
YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRLAA TQQNWDYRWQ QVPKIAWKKL
KLPGDSSLMT YRGHGVLHTL IRCRFSPAHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESDMNRV CSSGPTPVPC
PSVAFSSPQ
