ID   DCA11_PONAB             Reviewed;         546 AA.
AC   Q5R7H5; Q5REE4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DDB1- and CUL4-associated factor 11;
DE   AltName: Full=WD repeat-containing protein 23;
GN   Name=DCAF11; Synonyms=WDR23;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92285.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CR857585; CAH89863.1; -; mRNA.
DR   EMBL; CR860141; CAH92285.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001126335.1; NM_001132863.1.
DR   RefSeq; NP_001128756.1; NM_001135284.1.
DR   AlphaFoldDB; Q5R7H5; -.
DR   SMR; Q5R7H5; -.
DR   STRING; 9601.ENSPPYP00000006460; -.
DR   Ensembl; ENSPPYT00000006715; ENSPPYP00000006460; ENSPPYG00000005680.
DR   GeneID; 100173316; -.
DR   GeneID; 100189652; -.
DR   KEGG; pon:100173316; -.
DR   CTD; 80344; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00720000108873; -.
DR   HOGENOM; CLU_014280_3_1_1; -.
DR   InParanoid; Q5R7H5; -.
DR   OrthoDB; 1219799at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR017399; DCAF11/LEC14B.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..546
FT                   /note="DDB1- and CUL4-associated factor 11"
FT                   /id="PRO_0000373803"
FT   REPEAT          170..210
FT                   /note="WD 1"
FT   REPEAT          216..258
FT                   /note="WD 2"
FT   REPEAT          263..302
FT                   /note="WD 3"
FT   REPEAT          305..345
FT                   /note="WD 4"
FT   REPEAT          353..392
FT                   /note="WD 5"
FT   REPEAT          435..480
FT                   /note="WD 6"
FT   REPEAT          481..520
FT                   /note="WD 7"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         75
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VU6"
SQ   SEQUENCE   546 AA;  61631 MW;  0A332CE531048692 CRC64;
     MGSRNSSSAG SGSGDPSEGL TRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
     GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELECNEIK TQVELATGQL
     GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY
     SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG SHFLYSSWSD
     YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
     LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
     IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL
     KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
     NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPRSST
     PFSSPQ