ID   DCA11_RAT               Reviewed;         549 AA.
AC   Q5M9G8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=DDB1- and CUL4-associated factor 11;
DE   AltName: Full=WD repeat-containing protein 23;
GN   Name=Dcaf11; Synonyms=Wdr23;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
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DR   EMBL; BC087110; AAH87110.1; -; mRNA.
DR   EMBL; BC091364; AAH91364.1; -; mRNA.
DR   RefSeq; NP_001009686.1; NM_001009686.2.
DR   RefSeq; XP_006252033.1; XM_006251971.3.
DR   RefSeq; XP_017455174.1; XM_017599685.1.
DR   AlphaFoldDB; Q5M9G8; -.
DR   SMR; Q5M9G8; -.
DR   STRING; 10116.ENSRNOP00000056736; -.
DR   iPTMnet; Q5M9G8; -.
DR   PhosphoSitePlus; Q5M9G8; -.
DR   PaxDb; Q5M9G8; -.
DR   PRIDE; Q5M9G8; -.
DR   Ensembl; ENSRNOT00000077584; ENSRNOP00000074435; ENSRNOG00000018825.
DR   GeneID; 305895; -.
DR   KEGG; rno:305895; -.
DR   UCSC; RGD:1311288; rat.
DR   CTD; 80344; -.
DR   RGD; 1311288; Dcaf11.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00720000108873; -.
DR   InParanoid; Q5M9G8; -.
DR   OMA; MMSHFLP; -.
DR   OrthoDB; 1219799at2759; -.
DR   PhylomeDB; Q5M9G8; -.
DR   TreeFam; TF314126; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5M9G8; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000018825; Expressed in heart and 19 other tissues.
DR   Genevisible; Q5M9G8; RN.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR017399; DCAF11/LEC14B.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..549
FT                   /note="DDB1- and CUL4-associated factor 11"
FT                   /id="PRO_0000373804"
FT   REPEAT          170..210
FT                   /note="WD 1"
FT   REPEAT          216..258
FT                   /note="WD 2"
FT   REPEAT          263..302
FT                   /note="WD 3"
FT   REPEAT          305..345
FT                   /note="WD 4"
FT   REPEAT          353..392
FT                   /note="WD 5"
FT   REPEAT          435..480
FT                   /note="WD 6"
FT   REPEAT          481..520
FT                   /note="WD 7"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VU6"
FT   MOD_RES         75
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VU6"
SQ   SEQUENCE   549 AA;  61877 MW;  54D9A82ABF90ED72 CRC64;
     MGSRNSSSAG SGSLEPSEGL SRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
     GGAANLQLIQ ALSDSEEEHD SAWDGRLGDR YNPPVDATPD TRELEYNEIK TRVELATGRL
     GLGRTAQEHS FPRMLHQRER GLCHRGSFSL GEQSRVMSHF LPNDLSFTDT YSQKAFCGIY
     SKDGQIFMSA CQDQTIRLYD CRYGRFHKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD
     YIHICSIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
     LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
     IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRLAA TQQNWDYRWQ QVPKKAWKKL
     KLPGDSSLMT YRGHGVLHTL IRCRFSPAHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
     NHKACVRDVS WHPFEEKIVS SSWDGSLRLW QYRQAEYFQD DMTESDRNRV CSSGPAPVPC
     PSVAFSSPQ