ID   DCA13_CHICK             Reviewed;         445 AA.
AC   Q5ZLK1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DDB1- and CUL4-associated factor 13;
DE   AltName: Full=WD repeat and SOF domain-containing protein 1;
GN   Name=DCAF13; Synonyms=WDSOF1; ORFNames=RCJMB04_5m12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC       substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC       predominantly in the granular component, but also detected in the
CC       fibrillar center and dense fibrillar component.
CC       {ECO:0000250|UniProtKB:Q9NV06}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ719733; CAG31392.1; -; mRNA.
DR   RefSeq; NP_001026119.1; NM_001030948.1.
DR   AlphaFoldDB; Q5ZLK1; -.
DR   SMR; Q5ZLK1; -.
DR   STRING; 9031.ENSGALP00000025851; -.
DR   PaxDb; Q5ZLK1; -.
DR   GeneID; 420263; -.
DR   KEGG; gga:420263; -.
DR   CTD; 25879; -.
DR   VEuPathDB; HostDB:geneid_420263; -.
DR   eggNOG; KOG0268; Eukaryota.
DR   HOGENOM; CLU_033999_0_0_1; -.
DR   InParanoid; Q5ZLK1; -.
DR   OrthoDB; 418107at2759; -.
DR   PhylomeDB; Q5ZLK1; -.
DR   TreeFam; TF300844; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZLK1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR007287; Sof1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF04158; Sof1; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..445
FT                   /note="DDB1- and CUL4-associated factor 13"
FT                   /id="PRO_0000310431"
FT   REPEAT          64..104
FT                   /note="WD 1"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT   REPEAT          149..191
FT                   /note="WD 3"
FT   REPEAT          194..234
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..321
FT                   /note="WD 6"
FT   REPEAT          323..362
FT                   /note="WD 7"
SQ   SEQUENCE   445 AA;  51428 MW;  A96D7C17E60815A6 CRC64;
     MRVKVLSRNP DDYVRETKLD LQRVPRNYDP ALHPFEVARE YVRALNATKL ERVFAKPFLS
     SLDGHRDGVN CMAKHPKSLS TVLSGACDGE VRIWNLTKRQ CIRALQAHEG FVRGMCARFC
     GTSFFTVGDD KTVKQWKMES PGYGEEEEPI HTILGKTVYT GIDHHWKDAV FATCGQQVDI
     WDEQRTSPMC SLTWGFDSIS SVKFNPIETY LLGSCASDRN IVLYDMRQST PLKKVILNMR
     TNTLCWNPME AFIFTAANED YNLYTFDMRF LTSPVMVHMD HVSAVLDVDY SPTGKEFVSA
     SFDKSVRIFP VDKGHSREVY HTKRMQHVIT VKWTSDSRYI LCGSDEMNIR LWKANASEKL
     GVLAPREKAA MNYNQKLKEK FQHHPQIKRI ARHRHLPKSI YCQIKEQRIM REARRRKELN
     RRKHSKPGSV PVVSEKKKHI VAVVQ