ID   DCA13_DANRE             Reviewed;         445 AA.
AC   Q803X4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DDB1- and CUL4-associated factor 13;
DE   AltName: Full=WD repeat and SOF domain-containing protein 1;
GN   Name=dcaf13; Synonyms=wdsof1; ORFNames=zgc:55391;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC       substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC       predominantly in the granular component, but also detected in the
CC       fibrillar center and dense fibrillar component.
CC       {ECO:0000250|UniProtKB:Q9NV06}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC       {ECO:0000305}.
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DR   EMBL; BC044155; AAH44155.1; -; mRNA.
DR   RefSeq; NP_956423.1; NM_200129.1.
DR   AlphaFoldDB; Q803X4; -.
DR   SMR; Q803X4; -.
DR   STRING; 7955.ENSDARP00000028109; -.
DR   PaxDb; Q803X4; -.
DR   GeneID; 393097; -.
DR   KEGG; dre:393097; -.
DR   CTD; 25879; -.
DR   ZFIN; ZDB-GENE-040426-703; dcaf13.
DR   eggNOG; KOG0268; Eukaryota.
DR   InParanoid; Q803X4; -.
DR   OrthoDB; 418107at2759; -.
DR   PhylomeDB; Q803X4; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q803X4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR007287; Sof1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF04158; Sof1; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..445
FT                   /note="DDB1- and CUL4-associated factor 13"
FT                   /id="PRO_0000310432"
FT   REPEAT          64..104
FT                   /note="WD 1"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT   REPEAT          154..191
FT                   /note="WD 3"
FT   REPEAT          194..234
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..319
FT                   /note="WD 6"
FT   REPEAT          323..362
FT                   /note="WD 7"
FT   REGION          411..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  51333 MW;  551C78281F65858D CRC64;
     MKVKVLCRNP DDYVRETTRD IQRVPRNYDP TLHPFEVPRE YTRALNATKL ERVFAKPFVA
     SLDGHRDVIS CITKHAKSLS TVISGACDGE VKVWNLPKRE CTRTVQAHEG FVRGICSRFC
     GTSFFTVGDD KTIKQWNMEA PGYGVREEPI NTILGKAVFT GIDHHQREGT FVTCGQTVDI
     WDEQRSSPVL SFSWGVDSFS SVRYNPVEPD LLASCASDRS IVLYDTRESA PLRKVIMQLR
     SNTLCWNPME AYYFTCANED YNLYTYDIRN LDVPVTVHMD HVSAVLDVDY SPTGREFVSA
     SFDKTIRIFP KDKGHSREVY HTKRMQHVIC VKWSADSKFI MSGSDEMNIR LWKANASEKL
     GVLSTREKTA ANYNKKLIQK FQHHPQVRRI ARHRHLPRDV LKQKRELKEM KEARRRKEQN
     VRKHSKPGSV PLLTEKEKHV VKVVE