DCA13_MOUSE
ID DCA13_MOUSE Reviewed; 445 AA.
AC Q6PAC3; E9QPL0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=DDB1- and CUL4-associated factor 13;
DE AltName: Full=WD repeat and SOF domain-containing protein 1;
GN Name=Dcaf13; Synonyms=Gm83, Wdsof1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1. Interacts with ESR1 and LATS1.
CC {ECO:0000250|UniProtKB:Q9NV06}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC predominantly in the granular component, but also detected in the
CC fibrillar center and dense fibrillar component.
CC {ECO:0000250|UniProtKB:Q9NV06}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000305}.
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DR EMBL; AC164883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC165352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC060375; AAH60375.1; -; mRNA.
DR CCDS; CCDS37066.1; -.
DR RefSeq; NP_941008.2; NM_198606.2.
DR AlphaFoldDB; Q6PAC3; -.
DR SMR; Q6PAC3; -.
DR BioGRID; 230153; 31.
DR IntAct; Q6PAC3; 1.
DR STRING; 10090.ENSMUSP00000022909; -.
DR iPTMnet; Q6PAC3; -.
DR PhosphoSitePlus; Q6PAC3; -.
DR EPD; Q6PAC3; -.
DR MaxQB; Q6PAC3; -.
DR PaxDb; Q6PAC3; -.
DR PeptideAtlas; Q6PAC3; -.
DR PRIDE; Q6PAC3; -.
DR ProteomicsDB; 279279; -.
DR Antibodypedia; 26392; 107 antibodies from 15 providers.
DR DNASU; 223499; -.
DR Ensembl; ENSMUST00000022909; ENSMUSP00000022909; ENSMUSG00000022300.
DR GeneID; 223499; -.
DR KEGG; mmu:223499; -.
DR UCSC; uc007voc.2; mouse.
DR CTD; 25879; -.
DR MGI; MGI:2684929; Dcaf13.
DR VEuPathDB; HostDB:ENSMUSG00000022300; -.
DR eggNOG; KOG0268; Eukaryota.
DR GeneTree; ENSGT00390000005711; -.
DR HOGENOM; CLU_033999_0_0_1; -.
DR InParanoid; Q6PAC3; -.
DR OMA; MYDLRTS; -.
DR OrthoDB; 418107at2759; -.
DR PhylomeDB; Q6PAC3; -.
DR TreeFam; TF300844; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 223499; 22 hits in 77 CRISPR screens.
DR ChiTaRS; Dcaf13; mouse.
DR PRO; PR:Q6PAC3; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6PAC3; protein.
DR Bgee; ENSMUSG00000022300; Expressed in morula and 65 other tissues.
DR Genevisible; Q6PAC3; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; ISO:MGI.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..445
FT /note="DDB1- and CUL4-associated factor 13"
FT /id="PRO_0000310429"
FT REPEAT 64..104
FT /note="WD 1"
FT REPEAT 107..146
FT /note="WD 2"
FT REPEAT 149..191
FT /note="WD 3"
FT REPEAT 194..234
FT /note="WD 4"
FT REPEAT 236..276
FT /note="WD 5"
FT REPEAT 280..319
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT MOD_RES 49
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NV06"
FT CONFLICT 81
FT /note="S -> T (in Ref. 2; AAH60375)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 51456 MW; 30D2210E047B93FC CRC64;
MKVKMLSRNP DNYVRETKLD IQRVPRNYDP TLHPFEVPRE YVRALNATKL ERVFAKPFLA
SLDGHRDGVN CLAKHPKSLA SVLSGACDGE VKIWNLTKRK CIRTIQAHEG FVRGMCTRFC
GTSFFTVGDD KTVKQWKMDG PGYGEEEEPL YTVLGKTVYT GIDHHWKDPV FATCGQQVDI
WDEQRTSPVC SMNWGFDSIS SVKFNPVETF LLGSCASDRN IVLYDMRQAT PLKKVILEMR
TNTICWNPME AFNFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
SFDKSIRIFP VDKSRSREVY HTKRMQHVMC VKWTSDSKYI MCGSDEMNIR LWKANASEKL
GVLTSREKAA NDYNQKLKEK FQYHPHVKRI ARHRHLPKSI YSQIQEQRVM KEARRRKEMN
RRKHSKPGSV PIVSERKKHV VAVVK
