DCA13_PONAB
ID DCA13_PONAB Reviewed; 445 AA.
AC Q5R4T8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=DDB1- and CUL4-associated factor 13;
DE AltName: Full=WD repeat and SOF domain-containing protein 1;
GN Name=DCAF13; Synonyms=WDSOF1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1. Interacts with ESR1 and LATS1.
CC {ECO:0000250|UniProtKB:Q9NV06}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC predominantly in the granular component, but also detected in the
CC fibrillar center and dense fibrillar component.
CC {ECO:0000250|UniProtKB:Q9NV06}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000305}.
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DR EMBL; CR861153; CAH93228.1; -; mRNA.
DR RefSeq; NP_001126898.1; NM_001133426.1.
DR AlphaFoldDB; Q5R4T8; -.
DR SMR; Q5R4T8; -.
DR STRING; 9601.ENSPPYP00000021100; -.
DR GeneID; 100173913; -.
DR KEGG; pon:100173913; -.
DR CTD; 25879; -.
DR eggNOG; KOG0268; Eukaryota.
DR InParanoid; Q5R4T8; -.
DR OrthoDB; 418107at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..445
FT /note="DDB1- and CUL4-associated factor 13"
FT /id="PRO_0000310430"
FT REPEAT 64..104
FT /note="WD 1"
FT REPEAT 107..146
FT /note="WD 2"
FT REPEAT 149..191
FT /note="WD 3"
FT REPEAT 194..234
FT /note="WD 4"
FT REPEAT 236..276
FT /note="WD 5"
FT REPEAT 280..319
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT MOD_RES 49
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NV06"
SQ SEQUENCE 445 AA; 51320 MW; 1701B57368072089 CRC64;
MKVKMLSRNP DNYVRETKLD LQRVPRNYDP TLHPFEVPRE YVRALNATKL ERVFAKPFLA
SLDGHRDGVN CLAKHPKNLA TVLSGACDGE VRIWNLTQRN CIRTIQAHEG FVRGICTRFC
GTSFFTVGDD KTVKQWKMDG PGYGDEEEPL HTILGKTVYT GIDHHWKEAV FATCGQQVDI
WDEQRTNPVC SMTWGFDSIS SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR
TNTICWNPME AFIFTAANED YNLYTFDMSA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR LWKANASEKL
GVLTSREKAA KDYNQKLKEK FQHYPHIKRI ARHRHLPKSI YSQIQEQRIM KEARRRKEVN
RIKHSKPGSV PIVSEKKKHV VAVVK
