DCA13_SCHPO
ID DCA13_SCHPO Reviewed; 436 AA.
AC O74340;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Protein sof1;
DE AltName: Full=U3 small nucleolar RNA-associated protein sof1;
DE Short=U3 snoRNA-associated protein sof1;
GN Name=sof1; ORFNames=SPBC1A4.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for ribosomal RNA processing. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with snoRNA U3. Component of the ribosomal small
CC subunit (SSU) processome composed of at least 40 protein subunits and
CC snoRNA U3 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA20111.1; -; Genomic_DNA.
DR PIR; T39855; T39855.
DR RefSeq; NP_595809.1; NM_001021712.2.
DR AlphaFoldDB; O74340; -.
DR SMR; O74340; -.
DR BioGRID; 277315; 7.
DR STRING; 4896.SPBC1A4.07c.1; -.
DR MaxQB; O74340; -.
DR PaxDb; O74340; -.
DR EnsemblFungi; SPBC1A4.07c.1; SPBC1A4.07c.1:pep; SPBC1A4.07c.
DR GeneID; 2540796; -.
DR KEGG; spo:SPBC1A4.07c; -.
DR PomBase; SPBC1A4.07c; sof1.
DR VEuPathDB; FungiDB:SPBC1A4.07c; -.
DR eggNOG; KOG0268; Eukaryota.
DR HOGENOM; CLU_033999_0_0_1; -.
DR InParanoid; O74340; -.
DR OMA; MYDLRTS; -.
DR PhylomeDB; O74340; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-SPO-8951664; Neddylation.
DR PRO; PR:O74340; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..436
FT /note="Protein sof1"
FT /id="PRO_0000316545"
FT REPEAT 62..102
FT /note="WD 1"
FT REPEAT 105..143
FT /note="WD 2"
FT REPEAT 145..175
FT /note="WD 3"
FT REPEAT 176..225
FT /note="WD 4"
FT REPEAT 227..267
FT /note="WD 5"
FT REPEAT 271..310
FT /note="WD 6"
FT REPEAT 314..353
FT /note="WD 7"
FT REGION 411..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 49995 MW; 4846F514D2863510 CRC64;
MKVKTITRGT SLTRLNDQDP VKRNLDPSLH PFERAREYTR ALNATKMDRM FAAPFLGQLG
RGHQDGVYSL ARDTKTLIDC ASGSGDGAVK LWDASERCER WTSKAHEGIV RGLVFSNQGD
VLSCASDRYV YMLNKQDGKV KRSYLGDSSL LDIDTSKGGD LFATSGENVS IWDYSRDTPV
TKFEWGADTL PVVKFNYTET SVLASAGMDR SIVIYDLRTS SPLTKLITKL RTNSISWNPM
EAFNFVAGSE DHNLYMYDMR NLKRALHVYK DHVSAVMSVD FSPTGQEFVS GSYDKTIRIY
NVREGHSRDV YHTKRMQRVT AVKFSMDAQY IFSGSDDSNV RLWRARASSR ASIRSTREEN
RLKYLDSLRE RYKHIPEIRR IARHRHLPTN VKKAAEIKRE EINSLKRREE NIRRHSKKGA
VPYEKERERH VVGIQK
