ID   DCA13_XENLA             Reviewed;         445 AA.
AC   Q7ZYQ6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DDB1- and CUL4-associated factor 13;
DE   AltName: Full=WD repeat and SOF domain-containing protein 1;
GN   Name=dcaf13; Synonyms=wdsof1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC       substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC       predominantly in the granular component, but also detected in the
CC       fibrillar center and dense fibrillar component.
CC       {ECO:0000250|UniProtKB:Q9NV06}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC042261; AAH42261.1; -; mRNA.
DR   RefSeq; NP_001080629.1; NM_001087160.1.
DR   AlphaFoldDB; Q7ZYQ6; -.
DR   SMR; Q7ZYQ6; -.
DR   DNASU; 380321; -.
DR   GeneID; 380321; -.
DR   CTD; 380321; -.
DR   Xenbase; XB-GENE-5791341; dcaf13.L.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 380321; Expressed in testis and 19 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR007287; Sof1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF04158; Sof1; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..445
FT                   /note="DDB1- and CUL4-associated factor 13"
FT                   /id="PRO_0000310433"
FT   REPEAT          64..104
FT                   /note="WD 1"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT   REPEAT          152..191
FT                   /note="WD 3"
FT   REPEAT          194..234
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..319
FT                   /note="WD 6"
FT   REPEAT          323..362
FT                   /note="WD 7"
FT   REGION          413..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..445
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  51205 MW;  94F0348607285016 CRC64;
     MKVKVLCRNP DDYVRETKRD LQRVPRNYDP ALHPFEVSRE YTRALNATKL ERVFAKPFIA
     SLDGHRDGVN CIAKHPKSLS TVLSGACDGE VKIWNLTKRE CSRTIQAHDG FVRGLCVRFC
     GTSFFTVGDD KTVKQWAMES PGYGEKVEPM RTILGKTVFT GIDHHVKDAV FATCGQQVDI
     WDEQRSAPMR SYAWGVDSIS SVRFNPVETH ILSSCGTDRS IVLYDKRKPT PLKKIILEMR
     TNALCWNPME AFIFTAANEN FNLYTYDMRY MDSPVKVHMD HVSAVLDVDY SPTGKELVSA
     SFDKSIRIFP VQSGHSREVY HTKRMQHVTC VRWSADNKYV LCGSDEMNIR IWKANASEKL
     GVLSPRERAA QNYNQKLKEK FQHHPQIKRI ARHRHLPRSI YSQIKEQQIM REARRKKDVN
     RRKHSKPGSV PIPSEKKKHV LAVVE