ID   DCA13_XENTR             Reviewed;         445 AA.
AC   Q6NVS5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DDB1- and CUL4-associated factor 13;
DE   AltName: Full=WD repeat and SOF domain-containing protein 1;
GN   Name=dcaf13; Synonyms=wdsof1; ORFNames=TEgg103a13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC       substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes
CC       predominantly in the granular component, but also detected in the
CC       fibrillar center and dense fibrillar component.
CC       {ECO:0000250|UniProtKB:Q9NV06}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR855579; CAJ83694.1; -; mRNA.
DR   EMBL; BC067929; AAH67929.1; -; mRNA.
DR   RefSeq; NP_998858.1; NM_213693.1.
DR   AlphaFoldDB; Q6NVS5; -.
DR   SMR; Q6NVS5; -.
DR   PaxDb; Q6NVS5; -.
DR   GeneID; 407967; -.
DR   KEGG; xtr:407967; -.
DR   CTD; 25879; -.
DR   Xenbase; XB-GENE-5791289; dcaf13.
DR   eggNOG; KOG0268; Eukaryota.
DR   InParanoid; Q6NVS5; -.
DR   OrthoDB; 418107at2759; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004092; Expressed in blastula and 13 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR007287; Sof1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF04158; Sof1; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..445
FT                   /note="DDB1- and CUL4-associated factor 13"
FT                   /id="PRO_0000310434"
FT   REPEAT          64..104
FT                   /note="WD 1"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT   REPEAT          154..191
FT                   /note="WD 3"
FT   REPEAT          194..234
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..319
FT                   /note="WD 6"
FT   REPEAT          323..362
FT                   /note="WD 7"
FT   REGION          413..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..445
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  51302 MW;  32631BCC4C414E95 CRC64;
     MKVKVLCRNP DDYVRETKRD LQRVPRNYDP ALHPFEVPRE YTRALNATKL ERVFAKPFIA
     SLDGHRDGVN CIAKHPKSLS TVLSGACDGE VKIWNLTKRE CSRTIQAHDG FVRGLCVRFC
     GTSFFTVGDD KTVKQWSMES PGYGEKVEPI RTILGKTVFT GIDHHMNDAI FATCGQQVDI
     WDEQRSAPMR SYAWGVDSIS SIKFNPIETH ILSSCGTDRS IVLYDKRKPT PLKKIILEMR
     TNTLCWNPME AFIFTAANEN FNLYTYDMRY MDGPVKVHMD HVSAVLDVDY SPTGKEFVSA
     SFDKSIRIFP VQSGHSREVY HTKRMQHVTC VRWSADNKYV LCGSDEMNIR IWKANASEKL
     GLLSPRERAA QNYNQKLKEK FHHHPQIKRI ARHRHLPRSI YSQIKEQQIM REARRKKDVN
     RRKHSKPGSV PIPSEKKKHV LAVVE