ID   DCA15_XENLA             Reviewed;         600 AA.
AC   A2BDA5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=DDB1- and CUL4-associated factor 15 {ECO:0000250|UniProtKB:Q66K64};
GN   Name=dcaf15 {ECO:0000250|UniProtKB:Q66K64};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the DCX(DCAF15) complex, a
CC       cullin-4-RING E3 ubiquitin-protein ligase complex that mediates
CC       ubiquitination and degradation of target proteins. The DCX(DCAF15)
CC       complex acts as a regulator of the natural killer (NK) cells effector
CC       functions. {ECO:0000250|UniProtKB:Q66K64}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q66K64}.
CC   -!- SUBUNIT: Component of the DCX(DCAF15) complex, also named CLR4(DCAF15)
CC       complex. {ECO:0000250|UniProtKB:Q66K64}.
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DR   EMBL; BC130142; AAI30143.1; -; mRNA.
DR   RefSeq; NP_001091275.1; NM_001097806.1.
DR   AlphaFoldDB; A2BDA5; -.
DR   SMR; A2BDA5; -.
DR   MaxQB; A2BDA5; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   GO; GO:0032814; P:regulation of natural killer cell activation; ISS:UniProtKB.
DR   InterPro; IPR038914; DCAF15.
DR   InterPro; IPR032734; DCAF15_WD40.
DR   PANTHER; PTHR28541; PTHR28541; 1.
DR   Pfam; PF14939; DCAF15_WD40; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Metal-binding; Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN           1..600
FT                   /note="DDB1- and CUL4-associated factor 15"
FT                   /id="PRO_0000314487"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         193
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q66K64"
FT   BINDING         196
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q66K64"
FT   BINDING         211
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q66K64"
FT   BINDING         214
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q66K64"
SQ   SEQUENCE   600 AA;  66643 MW;  EB45516DD355C7A8 CRC64;
     MAPSSKSERN SGAGSAGGGP GGTGGKRAVG RRREHVLKQL ERVKISGQLS PRLFRKLPPR
     VCVSLKNIVD EDFLYAGHIF LGFSKCGRYV LSYTSSSGDD DFSFYIYHLY WWEFNVHSKL
     KLVRQVRLFQ DEEIYSDLYL TVCEWPSDAS KVIVFGFNTR SANGMLMNMM MMSDENHRDI
     YISTVAVPPR GRCAACQDAS RAHPGDPSAQ CLRHGFMLHT KYQVVYPFPT FQPAFQLKKD
     QVVLLNTSYS LVACAVSVHS AGDSSFCQIL YDHTALPPAP PSSPGPWSPE AAPAFPSLGV
     EVVPAQPSGA PEPSPAIAKA KEFVADIFRR AKEAKGSPLE ETRLPSSLGP SSSRCRPSLE
     PQAPSGEVVP RDSPPAAETT APEPGYINYT KLHYVLQSGE GTEPEDEFED DKISLPFVVT
     DLRGRNLRPM RERTDMQGQY LTVEQLTLDF EYVINEVIRH DATWGHQFCS FSDYDIVILE
     VCPETNQVLI NIGLLLLAFP APTEEGQLRP KTYHTSLKVA WDLNTGIFET VSVGDLTEVK
     GQTSGSVWSS YRKSCVDMVM KWLVPESSGR YVNRMTNEAL HKGCSLKVLA DSERYTWIVL