ID   DCA16_BOVIN             Reviewed;         175 AA.
AC   Q2HJA2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=DDB1- and CUL4-associated factor 16;
GN   Name=DCAF16;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a substrate recognition component for CUL4-DDB1
CC       E3 ubiquitin-protein ligase complex, which mediates ubiquitination and
CC       proteasome-dependent degradation of nuclear proteins.
CC       {ECO:0000250|UniProtKB:Q9NXF7}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250|UniProtKB:Q9NXF7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NXF7}.
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DR   EMBL; BC113235; AAI13236.1; -; mRNA.
DR   RefSeq; NP_001071615.1; NM_001078147.1.
DR   AlphaFoldDB; Q2HJA2; -.
DR   PaxDb; Q2HJA2; -.
DR   GeneID; 777600; -.
DR   KEGG; bta:777600; -.
DR   CTD; 54876; -.
DR   eggNOG; ENOG502RC7Y; Eukaryota.
DR   HOGENOM; CLU_111172_0_0_1; -.
DR   InParanoid; Q2HJA2; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR028216; DCAF16.
DR   PANTHER; PTHR16194; PTHR16194; 1.
DR   Pfam; PF15349; DCA16; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..175
FT                   /note="DDB1- and CUL4-associated factor 16"
FT                   /id="PRO_0000301963"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..39
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         61
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXF7"
SQ   SEQUENCE   175 AA;  19513 MW;  86E9136A320E4037 CRC64;
     MGPRNPSPDP LSESESEEEE NTNYLNESSG EEWDSSEEED PVVPNLTPLE SLAWQVKCLL
     KYSTTWKPLN PNSWLYHAKL LDASTPVHIL REIGLRLSHC SHCVPKLEPI PEWPPLASCG
     VPPFQKPLIS PSRLSRDHAT LNGALQFATK QLSRTLSRAT PHAFLPKLVP LAFSS