DCA17_DANRE
ID DCA17_DANRE Reviewed; 526 AA.
AC A8WHR0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=DDB1- and CUL4-associated factor 17;
GN Name=dcaf17; ORFNames=si:ch211-245g15.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000250}. Note=Has been
CC shown in human and mouse to be a nucleolar protein, while sequence
CC analysis programs clearly predict 2 transmembrane regions.
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DR EMBL; BX248116; CAP19550.1; -; Genomic_DNA.
DR RefSeq; NP_001138261.1; NM_001144789.1.
DR AlphaFoldDB; A8WHR0; -.
DR STRING; 7955.ENSDARP00000121682; -.
DR PaxDb; A8WHR0; -.
DR Ensembl; ENSDART00000145043; ENSDARP00000121682; ENSDARG00000074909.
DR GeneID; 558828; -.
DR KEGG; dre:558828; -.
DR CTD; 80067; -.
DR ZFIN; ZDB-GENE-071008-1; dcaf17.
DR eggNOG; ENOG502QQ41; Eukaryota.
DR GeneTree; ENSGT00390000012728; -.
DR HOGENOM; CLU_604033_0_0_1; -.
DR InParanoid; A8WHR0; -.
DR OMA; YCKFRRY; -.
DR PhylomeDB; A8WHR0; -.
DR TreeFam; TF328801; -.
DR Reactome; R-DRE-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR PRO; PR:A8WHR0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000074909; Expressed in cleaving embryo and 26 other tissues.
DR ExpressionAtlas; A8WHR0; baseline and differential.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR031620; DCAF17.
DR PANTHER; PTHR14815; PTHR14815; 1.
DR Pfam; PF15802; DCAF17; 1.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix;
KW Ubl conjugation pathway.
FT CHAIN 1..526
FT /note="DDB1- and CUL4-associated factor 17"
FT /id="PRO_0000359591"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 526 AA; 59698 MW; 11723D0B49A5944F CRC64;
MCALPSPRAQ RPPACTRTSK NSCALLASRY NGSCSNDFGR LLASNLKILR NIILKDDTEF
VKVWSKTSKS LISYESGRIY FDNYRCCYSS LLPEPELLYE LPRTPKTEKI EDALLCQCPL
ENVLPNASEQ KSCLLTLTAN NWLYLLSADT GETLQRVYLS SRFKFSRSLG WDSSQETFYV
KSVQCKQTAL ERQAGVDNNI LMRVAAFQVF PLQLVGMLEI NKKVFGKTAV DVLLSQGVLA
VSHSSKLVRL YSFEYIVNKF RTEELILGQQ CELNNARGIV GDAPYGVPVN ICIHECPPVL
FEMTYFENGV QIGGHPWHYI YTPNHKRHRG THHVCSITDG ALAKNGVQDM KCDSLEVDWI
FFHPDDSGRI IHAGPSTINI LKIMAETGCD WKYEIITDFS ITAARDSNAS QVIVTSSGRT
VKRRFQMLDD DPAQETFRMV KYEDELDLLA VVDITHAEDE GQARLRLHDN KTGALMKRVP
LEEPWDVTYS HEVYFDRDTI IHTVQEKNNS FCCHVYKMKR PASDQP