DCA17_MOUSE
ID DCA17_MOUSE Reviewed; 519 AA.
AC Q3TUL7; A2AUU6; Q8C002; Q8K0F5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=DDB1- and CUL4-associated factor 17;
GN Name=Dcaf17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=19026396; DOI=10.1016/j.ajhg.2008.10.018;
RA Alazami A.M., Al-Saif A., Al-Semari A., Bohlega S., Zlitni S.,
RA Alzahrani F., Bavi P., Kaya N., Colak D., Khalak H., Baltus A.,
RA Peterlin B., Danda S., Bhatia K.P., Schneider S.A., Sakati N., Walsh C.A.,
RA Al-Mohanna F., Meyer B., Alkuraya F.S.;
RT "Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism,
RT alopecia, diabetes mellitus, mental retardation, and extrapyramidal
RT syndrome.";
RL Am. J. Hum. Genet. 83:684-691(2008).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1, CUL4A and CUL4B. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Nucleus, nucleolus
CC {ECO:0000269|PubMed:19026396}. Note=According to PubMed:19026396, it is
CC a nucleolar protein, while sequence analysis programs clearly predict 2
CC transmembrane regions.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3TUL7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TUL7-2; Sequence=VSP_027789;
CC Name=3;
CC IsoId=Q3TUL7-3; Sequence=VSP_027790, VSP_027791;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in the embryo, with higher
CC expression in brain, liver and skin tissues.
CC {ECO:0000269|PubMed:19026396}.
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DR EMBL; AK032671; BAC27979.1; -; mRNA.
DR EMBL; AK160679; BAE35954.1; -; mRNA.
DR EMBL; AL929228; CAM22153.1; -; Genomic_DNA.
DR EMBL; AL929228; CAM22154.1; -; Genomic_DNA.
DR EMBL; AL929228; CAM22155.1; -; Genomic_DNA.
DR EMBL; BC031546; AAH31546.1; -; mRNA.
DR CCDS; CCDS16111.1; -. [Q3TUL7-2]
DR CCDS; CCDS50601.1; -. [Q3TUL7-1]
DR CCDS; CCDS50602.1; -. [Q3TUL7-3]
DR RefSeq; NP_001159452.1; NM_001165980.1. [Q3TUL7-1]
DR RefSeq; NP_001159453.1; NM_001165981.1. [Q3TUL7-1]
DR RefSeq; NP_001159454.1; NM_001165982.1. [Q3TUL7-3]
DR RefSeq; NP_932122.2; NM_198005.2.
DR RefSeq; XP_006500402.1; XM_006500339.3. [Q3TUL7-1]
DR AlphaFoldDB; Q3TUL7; -.
DR BioGRID; 217721; 1.
DR STRING; 10090.ENSMUSP00000120016; -.
DR PhosphoSitePlus; Q3TUL7; -.
DR EPD; Q3TUL7; -.
DR PaxDb; Q3TUL7; -.
DR PRIDE; Q3TUL7; -.
DR ProteomicsDB; 279879; -. [Q3TUL7-1]
DR ProteomicsDB; 279880; -. [Q3TUL7-2]
DR ProteomicsDB; 279881; -. [Q3TUL7-3]
DR Antibodypedia; 65882; 40 antibodies from 13 providers.
DR Ensembl; ENSMUST00000064141; ENSMUSP00000065624; ENSMUSG00000041966. [Q3TUL7-1]
DR Ensembl; ENSMUST00000112159; ENSMUSP00000107785; ENSMUSG00000041966. [Q3TUL7-3]
DR Ensembl; ENSMUST00000154704; ENSMUSP00000120016; ENSMUSG00000041966. [Q3TUL7-1]
DR GeneID; 75763; -.
DR KEGG; mmu:75763; -.
DR UCSC; uc008kab.2; mouse. [Q3TUL7-3]
DR UCSC; uc008kad.2; mouse. [Q3TUL7-1]
DR CTD; 80067; -.
DR MGI; MGI:1923013; Dcaf17.
DR VEuPathDB; HostDB:ENSMUSG00000041966; -.
DR eggNOG; ENOG502QQ41; Eukaryota.
DR GeneTree; ENSGT00390000012728; -.
DR HOGENOM; CLU_604033_0_0_1; -.
DR InParanoid; Q3TUL7; -.
DR OMA; YCKFRRY; -.
DR OrthoDB; 1292766at2759; -.
DR PhylomeDB; Q3TUL7; -.
DR TreeFam; TF328801; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 75763; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Dcaf17; mouse.
DR PRO; PR:Q3TUL7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3TUL7; protein.
DR Bgee; ENSMUSG00000041966; Expressed in ear vesicle and 246 other tissues.
DR ExpressionAtlas; Q3TUL7; baseline and differential.
DR Genevisible; Q3TUL7; MM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR031620; DCAF17.
DR PANTHER; PTHR14815; PTHR14815; 1.
DR Pfam; PF15802; DCAF17; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix; Ubl conjugation pathway.
FT CHAIN 1..519
FT /note="DDB1- and CUL4-associated factor 17"
FT /id="PRO_0000300119"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 245..286
FT /note="FMQQKLDLGCACSQGGTTGTVGEAPFGIPCNVKITDSPPPLF -> THHLHS
FT LKFHLWRTHSRLEAILGTTSSRLIRRNRKEFFIFVP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027790"
FT VAR_SEQ 287..519
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027791"
FT VAR_SEQ 474..519
FT /note="TYSHEVYFDRDLVLHIEQKPNRVFSCYVYQMVCDPGEEEEAVNRSG -> VC
FT IMSGTLSCKGFLYRCHLLDHVHISPDSPVL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027789"
FT CONFLICT Q3TUL7-2:477
FT /note="M -> T (in Ref. 2; CAM22154)"
FT /evidence="ECO:0000305"
FT CONFLICT Q3TUL7-2:504
FT /note="V -> M (in Ref. 2; CAM22154)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 519 AA; 58400 MW; E22D2926D3FDAFD6 CRC64;
MGRTRKANVC RRLSRRALGF YARDAGVVQR TNLGILRALV CQESTKFKNV WTTHSKSPIA
YERGRIYFDN YRCCVSSVAS EPRKLYEMPK CSKSEKIEDA LLWECPVGDI LPDPSDYKSS
LIALTAHNWL LRISATTGEV LEKIYLASYC KFRYLSWDTP QEVIAVKSAQ NKGSAAARQA
GTSPPVLLYL AVFRVLPFSL VGILEINKKV FENVTDATLS HGILIVMYSS GLVRLYSFQA
IIEQFMQQKL DLGCACSQGG TTGTVGEAPF GIPCNVKITD SPPPLFEVSS LENAFQIGGH
PWHYIITPNK KKQKGVFHIC ALKDNSLAKN GIQEMECCSL ESDWIYFHPD ASGRIIHVGP
NQVKVLKLSE VENDSSQHQI SEDFVIWAKR EDRKENLITV TASGRVVKRN VSLLDDDPEQ
ETFKIVDYED ELDLLSVVAV TQIDAEGKAH LDFHCNEYGT LLKSIPLVES WDVTYSHEVY
FDRDLVLHIE QKPNRVFSCY VYQMVCDPGE EEEAVNRSG
