ID   DCA17_RAT               Reviewed;         505 AA.
AC   B1H299;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=DDB1- and CUL4-associated factor 17;
GN   Name=Dcaf17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with DDB1, CUL4A and CUL4B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000250}. Note=Has been
CC       shown in human and mouse to be a nucleolar protein, while sequence
CC       analysis programs clearly predict 2 transmembrane regions.
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DR   EMBL; BC160919; AAI60919.1; -; mRNA.
DR   RefSeq; NP_001171159.1; NM_001177688.1.
DR   AlphaFoldDB; B1H299; -.
DR   STRING; 10116.ENSRNOP00000031374; -.
DR   PaxDb; B1H299; -.
DR   GeneID; 499807; -.
DR   KEGG; rno:499807; -.
DR   UCSC; RGD:1565551; rat.
DR   CTD; 80067; -.
DR   RGD; 1565551; Dcaf17.
DR   eggNOG; ENOG502QQ41; Eukaryota.
DR   HOGENOM; CLU_604033_0_0_1; -.
DR   InParanoid; B1H299; -.
DR   PhylomeDB; B1H299; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:B1H299; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; B1H299; RN.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR031620; DCAF17.
DR   PANTHER; PTHR14815; PTHR14815; 1.
DR   Pfam; PF15802; DCAF17; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway.
FT   CHAIN           1..505
FT                   /note="DDB1- and CUL4-associated factor 17"
FT                   /id="PRO_0000363890"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   505 AA;  56450 MW;  90D4945B65EC4AAB CRC64;
     MGRTRKANVC PRLSRRALGF YTRDAGVVQR TNLGILRALV CQESTKFKNV WTTHSKSPIA
     YERGRIYFDN YRCCVSSVAS EPRKLYEMPK CSKSEKIEDA LLWECPVGEI LPDPSDYKSS
     LIALTAHNWL LRISATTGEI LEKIYLASYC KFRYLSWDTP QEVIAVKSAQ NKGSAAARQA
     GTQPPVLLYL AVFRVLPFSL VGILEINRKV FENVTDATLS HGILIVMYSS GLVRLYSFQA
     IIEQFMQQKL DLGCACSQGG TTGTVGEAPF GIPCNVKITD SPPPLFEVSS LENAFQIGGH
     PWHYIITPNK KKQKGVFHIC ALKDNSLAKN GIQEMECCSL ESDWIYFHPD ASGRIIHVGP
     NQVKVLKLSE VENNSSQHQI SEDFVIWANR EDRKENLITV TASGRVVKRN VNLLDDDPEQ
     ETFKVVDYED ELNLLSVVAV TQIDAEGKAH LDFHCNEYGT LLKSIPLVES WDVVCITTGT
     LSCKGFLYKR HLLGHVLVSP DSPVP