ID   DCAF4_BOVIN             Reviewed;         494 AA.
AC   Q58DC2;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=DDB1- and CUL4-associated factor 4;
DE   AltName: Full=WD repeat-containing protein 21A;
GN   Name=DCAF4; Synonyms=WDR21A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
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DR   EMBL; BT021675; AAX46522.1; -; mRNA.
DR   RefSeq; NP_001019691.1; NM_001024520.1.
DR   AlphaFoldDB; Q58DC2; -.
DR   SMR; Q58DC2; -.
DR   STRING; 9913.ENSBTAP00000011481; -.
DR   PaxDb; Q58DC2; -.
DR   PRIDE; Q58DC2; -.
DR   GeneID; 511629; -.
DR   KEGG; bta:511629; -.
DR   CTD; 26094; -.
DR   eggNOG; KOG2695; Eukaryota.
DR   InParanoid; Q58DC2; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..494
FT                   /note="DDB1- and CUL4-associated factor 4"
FT                   /id="PRO_0000245504"
FT   REPEAT          367..406
FT                   /note="WD 1"
FT   REPEAT          409..450
FT                   /note="WD 2"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  55024 MW;  E533BA299A69A44A CRC64;
     MHQSSWKSRR HRRRGHRHSA WFRQHGSNER KDAGAQQSPQ GSSDGHGEAP STSSTAGSSS
     VPDLPGYYFD PEKKRYFRLL PGHNNCNPLT KESIRQKEME RKRLRLLEEE EQQGKKIARL
     GFNASSLLQK SKLGFLNATS YCRLAHELQV SCMQRKKVQI QSSDPSALAS DQFNLIMADT
     NSDRLFTVND VKVGGSKYGI ISLHGLKTPT FRVHMHENLY FTNRKVNAMC WASLNHLDSH
     VLLCLMGIAE TPGCATLLPT SLFVSNHAAG DRPGMLCSFR IPGAWSCAWS LNIQANNCFS
     TGLSRRVLVT SVVTGHRQSF GTSSDVLTQQ FAVTAPLLFN GCRSGEIFAI DLRCQNQGKG
     WKATCLFHDS AVTSVQILQE EQCLMASDMA GTIKLWDLRT TKCIRQYEGH VNEYAHLPLH
     VHEEEGIMVA VGQDCYTRIW SLHDGQLLRT IPSPYPTSKA DIPSVAFSSR LGGARGAPGL
     LMAVRQDLYC FSYS