ID   DCAF7_DICDI             Reviewed;         325 AA.
AC   Q552R1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=DDB1- and CUL4-associated factor 7 homolog;
DE   AltName: Full=WD repeat-containing protein 68 homolog;
GN   Name=wdr68; ORFNames=DDB_G0275925;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000013; EAL69713.2; -; Genomic_DNA.
DR   RefSeq; XP_643620.2; XM_638528.2.
DR   AlphaFoldDB; Q552R1; -.
DR   SMR; Q552R1; -.
DR   STRING; 44689.DDB0267164; -.
DR   PaxDb; Q552R1; -.
DR   EnsemblProtists; EAL69713; EAL69713; DDB_G0275925.
DR   GeneID; 8620207; -.
DR   KEGG; ddi:DDB_G0275925; -.
DR   dictyBase; DDB_G0275925; wdr68.
DR   eggNOG; KOG0290; Eukaryota.
DR   HOGENOM; CLU_013694_0_0_1; -.
DR   InParanoid; Q552R1; -.
DR   OMA; INQIQWG; -.
DR   PhylomeDB; Q552R1; -.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   PRO; PR:Q552R1; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045159; DCAF7-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19919; PTHR19919; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..325
FT                   /note="DDB1- and CUL4-associated factor 7 homolog"
FT                   /id="PRO_0000328380"
FT   REPEAT          62..104
FT                   /note="WD 1"
FT   REPEAT          115..155
FT                   /note="WD 2"
FT   REPEAT          158..197
FT                   /note="WD 3"
FT   REPEAT          247..287
FT                   /note="WD 4"
SQ   SEQUENCE   325 AA;  36819 MW;  CE35C49B0A00D5A8 CRC64;
     MEKKRIYTYN SPWVIYGLSW SSRVNRPFRL AIGSFLEDYT NRVDVIQLNE ETDQFEVVCG
     FEHPYPPTKC MWIPDKNSNR PDLLATTGDY LRLWEVGSNQ RSIKLKSLLT NVISEFCAPL
     SSFDWNETDP SLLATSSIDT TCTIWNIETG QAKTQLIAHD KEVFDIAFAR GTDLFASVGA
     DGSLRMFDLR NLEHSTIIYE TPSFVPLLRL CWNKQDPNYL ATIQQDSPKV IILDIRVPSV
     PAAELVFHKS AVNGISWAPH SSCHICTVSD DKQALIWDLS SMPKPIEDPL LTYNALAEIN
     QLSWSSSQPD WIAIAFSSHL QILKV