DCAF7_MOUSE
ID DCAF7_MOUSE Reviewed; 342 AA.
AC P61963; O15491; Q3TMV9; Q9DAE4;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=DDB1- and CUL4-associated factor 7;
DE AltName: Full=WD repeat-containing protein 68;
DE AltName: Full=WD repeat-containing protein An11 homolog;
GN Name=Dcaf7; Synonyms=Han11, Wdr68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=16887337; DOI=10.1016/j.jdermsci.2006.06.001;
RA Morita K., Lo Celso C., Spencer-Dene B., Zouboulis C.C., Watt F.M.;
RT "HAN11 binds mDia1 and controls GLI1 transcriptional activity.";
RL J. Dermatol. Sci. 44:11-20(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in craniofacial development. Acts upstream of the
CC EDN1 pathway and is required for formation of the upper jaw equivalent,
CC the palatoquadrate. The activity required for EDN1 pathway function
CC differs between the first and second arches. Associates with DIAPH1 and
CC controls GLI1 transcriptional activity. Could be involved in skin
CC development. May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1.
CC Interacts with ZNF703 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}.
CC Note=Overexpression of DIAHP1 or active RHOA causes translocation from
CC the nucleus to cytoplasm.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in 10.5 dpc embryo limb buds, in
CC an overlapping pattern with PTCH1 and GLI1.
CC {ECO:0000269|PubMed:16887337}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK005902; BAB24308.1; -; mRNA.
DR EMBL; AK047435; BAC33058.1; -; mRNA.
DR EMBL; AK165674; BAE38331.1; -; mRNA.
DR EMBL; BC048722; AAH48722.1; -; mRNA.
DR CCDS; CCDS25546.1; -.
DR RefSeq; NP_082222.1; NM_027946.3.
DR AlphaFoldDB; P61963; -.
DR SMR; P61963; -.
DR BioGRID; 214962; 27.
DR IntAct; P61963; 3.
DR MINT; P61963; -.
DR STRING; 10090.ENSMUSP00000058168; -.
DR iPTMnet; P61963; -.
DR PhosphoSitePlus; P61963; -.
DR SwissPalm; P61963; -.
DR REPRODUCTION-2DPAGE; P61963; -.
DR EPD; P61963; -.
DR MaxQB; P61963; -.
DR PaxDb; P61963; -.
DR PeptideAtlas; P61963; -.
DR PRIDE; P61963; -.
DR ProteomicsDB; 279883; -.
DR Antibodypedia; 9425; 185 antibodies from 26 providers.
DR DNASU; 71833; -.
DR Ensembl; ENSMUST00000058438; ENSMUSP00000058168; ENSMUSG00000049354.
DR GeneID; 71833; -.
DR KEGG; mmu:71833; -.
DR UCSC; uc007lxy.1; mouse.
DR CTD; 10238; -.
DR MGI; MGI:1919083; Dcaf7.
DR VEuPathDB; HostDB:ENSMUSG00000049354; -.
DR eggNOG; KOG0290; Eukaryota.
DR GeneTree; ENSGT00390000006939; -.
DR HOGENOM; CLU_013694_0_0_1; -.
DR InParanoid; P61963; -.
DR OMA; INQIQWG; -.
DR OrthoDB; 750776at2759; -.
DR PhylomeDB; P61963; -.
DR TreeFam; TF106135; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 71833; 15 hits in 77 CRISPR screens.
DR ChiTaRS; Dcaf7; mouse.
DR PRO; PR:P61963; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P61963; protein.
DR Bgee; ENSMUSG00000049354; Expressed in superior cervical ganglion and 219 other tissues.
DR Genevisible; P61963; MM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0016363; C:nuclear matrix; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045159; DCAF7-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19919; PTHR19919; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..342
FT /note="DDB1- and CUL4-associated factor 7"
FT /id="PRO_0000051426"
FT REPEAT 66..108
FT /note="WD 1"
FT REPEAT 118..160
FT /note="WD 2"
FT REPEAT 172..214
FT /note="WD 3"
FT REPEAT 264..304
FT /note="WD 4"
SQ SEQUENCE 342 AA; 38926 MW; 794CC69A45D0CC7C CRC64;
MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI
CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC
APLTSFDWNE VDPYLLGTSS IDTTCTIWGL ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI
AFSRAGGGRD MFASVGADGS VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM
AMDGMEVVIL DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP
RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV
