ID   DCAF8_XENLA             Reviewed;         601 AA.
AC   Q6NRH1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DDB1- and CUL4-associated factor 8;
DE   AltName: Full=WD repeat-containing protein 42A;
GN   Name=dcaf8; Synonyms=wdr42a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TAQ9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5TAQ9}. Note=It shuttles between the nucleus
CC       and the cytoplasm. {ECO:0000250|UniProtKB:Q5TAQ9}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF8 family. {ECO:0000305}.
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DR   EMBL; BC070779; AAH70779.1; -; mRNA.
DR   RefSeq; NP_001084901.1; NM_001091432.1.
DR   AlphaFoldDB; Q6NRH1; -.
DR   SMR; Q6NRH1; -.
DR   BioGRID; 101318; 1.
DR   IntAct; Q6NRH1; 1.
DR   MaxQB; Q6NRH1; -.
DR   PRIDE; Q6NRH1; -.
DR   DNASU; 431952; -.
DR   GeneID; 431952; -.
DR   KEGG; xla:431952; -.
DR   CTD; 431952; -.
DR   Xenbase; XB-GENE-989777; dcaf8.S.
DR   OrthoDB; 1270484at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 431952; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045151; DCAF8.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15574; PTHR15574; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..601
FT                   /note="DDB1- and CUL4-associated factor 8"
FT                   /id="PRO_0000296962"
FT   REPEAT          194..233
FT                   /note="WD 1"
FT   REPEAT          237..278
FT                   /note="WD 2"
FT   REPEAT          284..324
FT                   /note="WD 3"
FT   REPEAT          332..372
FT                   /note="WD 4"
FT   REPEAT          388..427
FT                   /note="WD 5"
FT   REPEAT          435..475
FT                   /note="WD 6"
FT   REPEAT          479..519
FT                   /note="WD 7"
FT   REGION          1..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          94..131
FT                   /evidence="ECO:0000255"
FT   MOTIF           39..50
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TAQ9"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   601 AA;  67108 MW;  3DDCED0AEF9F891D CRC64;
     MSFSGEMSNG KTDVTNGGFS SSPEDMSGAE EGKENSSGIE VEASDVSLSL TADETGTTQA
     ESRDSCSETS GEDKDSDSMD DTGHYSINDE NRGNDQSHSE DEEEEEEEDE EEEAVRHRKR
     AQRKRANRDQ ESSDEERALD DWLISEKTPL PPPQWRALSA LRQRQMGSST RFIYEACGAR
     GFVQRFHLLH GLDGHSGCVN TLHFNQRGTC LASGSDDLKV VVWDWVRRKP VLEFESGHKS
     NVFQAKFLPN SGDSTLAMCA RDGQVRVAEL SATHCCKNTK RVAQHKGASH KLALEPDSPC
     TFLSAGEDAV VFTIDLRQDR PASRLVVTKE KESKVGLYTI YVNPANTYQF AVGGRDQFVR
     IYDQRKINEN VNNGVLKKFC PHHLVTSEAK ANITCLVYSH DGSELLASYN DEDIYLFNSS
     HSDGAEYIKR YKGHRNNATV KGVNFYGPRS EFVVSGSDCG HIFLWEKSSC QIVQFMDGDK
     GGVVNCLEPH PHLPVLATSG LDYDVKIWLP TAKEPTELDG LKEVIKKNKR ERDEDSLHHT
     DLFDNHMLWF LMHHLRQRGQ RRRRRDAGLG AGDAESDDSP SSSDSSDDDE DGPDRVQCIP
     S