ID   DCAF8_XENTR             Reviewed;         604 AA.
AC   Q28I90;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DDB1- and CUL4-associated factor 8;
DE   AltName: Full=WD repeat-containing protein 42A;
GN   Name=dcaf8; Synonyms=wdr42a; ORFNames=TEgg075a15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TAQ9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5TAQ9}. Note=It shuttles between the nucleus
CC       and the cytoplasm. {ECO:0000250|UniProtKB:Q5TAQ9}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF8 family. {ECO:0000305}.
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DR   EMBL; CR760529; CAJ81403.1; -; mRNA.
DR   EMBL; BC135344; AAI35345.1; -; mRNA.
DR   RefSeq; NP_001016610.1; NM_001016610.1.
DR   RefSeq; XP_017951752.1; XM_018096263.1.
DR   AlphaFoldDB; Q28I90; -.
DR   SMR; Q28I90; -.
DR   STRING; 8364.ENSXETP00000017785; -.
DR   DNASU; 549364; -.
DR   GeneID; 549364; -.
DR   KEGG; xtr:549364; -.
DR   CTD; 50717; -.
DR   Xenbase; XB-GENE-989771; dcaf8.
DR   eggNOG; KOG1334; Eukaryota.
DR   InParanoid; Q28I90; -.
DR   OrthoDB; 1270484at2759; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045151; DCAF8.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15574; PTHR15574; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..604
FT                   /note="DDB1- and CUL4-associated factor 8"
FT                   /id="PRO_0000296961"
FT   REPEAT          197..236
FT                   /note="WD 1"
FT   REPEAT          240..281
FT                   /note="WD 2"
FT   REPEAT          287..327
FT                   /note="WD 3"
FT   REPEAT          335..375
FT                   /note="WD 4"
FT   REPEAT          391..430
FT                   /note="WD 5"
FT   REPEAT          438..478
FT                   /note="WD 6"
FT   REPEAT          482..522
FT                   /note="WD 7"
FT   REGION          1..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           39..50
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TAQ9"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..114
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   604 AA;  67794 MW;  6F66D2CA4F00D59D CRC64;
     MSFSGEMANG KTDVANSGFS SSPEDMSGAE EGKENSSGIE VEASDVSLSL TGDETGTTQA
     ESRDTCSETS GEDKDSDSMD DTGHYSINDE NRGNDQSHSE DEEEEEEEEE DEEEEEAVRH
     RKRAQRKRAN RDQDSSDEER ALEDWVLSEK TPLPRPRWRA LRALRQRQMG SSTRFIYDAC
     GARGFVQRFR LLHGLDGHSG CVNTLHFNQR GTWLASGSDD LKVVVWDWVR RKPVLEFESG
     HKSNVFQAKF LPNSGDSTLA MCARDGQVRV AELSATHCCK NTKRVAQHKG ASHKLALERD
     SPCTFLSAGE DAVVFTIDLR QDRPASRLVV TKEKEKKVGL YTIYVNPANT YQFAVGGRDQ
     FVRIYDQRKI NENVNNGVLK KFCPHHLVTS EAKANITCLV YSHDGSELLA SYNDEDIYLF
     NSSHSDGAEY IKRYKGHRNN ATVKGVNFYG PRSEFVVSGS DCGHIFLWEK SSCQIVQFMD
     GDKGGVVNCL EPHPHLPVLA TSGLDYDVKI WLPTAKEPTE LNGLKEVIKK NKRERDEDSL
     HHTDLFDNHM LWFLMHHLRQ RGQRRRRRDA GLGAGDADSD DSPSSSDSSD DDEDGPDRVQ
     CIPS