ID   DCAKD_BOVIN             Reviewed;         231 AA.
AC   Q3ZBS0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Dephospho-CoA kinase domain-containing protein;
GN   Name=DCAKD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RT   "Bovine genome sequencing program: full-length cDNA sequencing.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3ZBS0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3ZBS0-2; Sequence=VSP_030808, VSP_030809;
CC   -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DV815527; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC103143; AAI03144.1; -; mRNA.
DR   RefSeq; NP_001071349.1; NM_001077881.1. [Q3ZBS0-2]
DR   RefSeq; XP_005220892.1; XM_005220835.3.
DR   AlphaFoldDB; Q3ZBS0; -.
DR   SMR; Q3ZBS0; -.
DR   STRING; 9913.ENSBTAP00000007945; -.
DR   PaxDb; Q3ZBS0; -.
DR   PRIDE; Q3ZBS0; -.
DR   GeneID; 508778; -.
DR   KEGG; bta:508778; -.
DR   CTD; 79877; -.
DR   eggNOG; KOG3220; Eukaryota.
DR   HOGENOM; CLU_057180_0_0_1; -.
DR   InParanoid; Q3ZBS0; -.
DR   OrthoDB; 1263008at2759; -.
DR   TreeFam; TF314815; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IBA:GO_Central.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01121; CoaE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00152; TIGR00152; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..231
FT                   /note="Dephospho-CoA kinase domain-containing protein"
FT                   /id="PRO_0000316848"
FT   DOMAIN          3..207
FT                   /note="DPCK"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         135
FT                   /note="C -> W (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_030808"
FT   VAR_SEQ         136..231
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_030809"
SQ   SEQUENCE   231 AA;  26384 MW;  D6123D129314C743 CRC64;
     MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDIIARHIVQ PGYPAHRRIV EAFGTEVLLE
     NGDIDRKVLG DLIFNQPDRR HLLNSITHPE ICKEMMKETF KYFLRGYRYV ILDIPLLFET
     KKLLKYMKHT VVVYCDRDTQ LARLMRRNNL SREDAEARIK AQLPLKDKAR MARHVLDNSG
     EWSVTKRQVV LLHAELEHSL EYLPLRLGVL TGLAGIVGLL YLLTHYLLPS P