DCAKD_HUMAN
ID DCAKD_HUMAN Reviewed; 231 AA.
AC Q8WVC6; A8K3Z0; D3DX60; D3DX62; Q9BR71; Q9H5W1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Dephospho-CoA kinase domain-containing protein;
GN Name=DCAKD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-84.
RC TISSUE=Brain, Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WVC6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVC6-2; Sequence=VSP_030810, VSP_030811;
CC -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000305}.
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DR EMBL; AK026608; BAB15508.1; -; mRNA.
DR EMBL; AK290755; BAF83444.1; -; mRNA.
DR EMBL; CH471178; EAW51558.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51559.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51560.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51561.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51562.1; -; Genomic_DNA.
DR EMBL; BC006472; AAH06472.1; -; mRNA.
DR EMBL; BC006546; AAH06546.1; -; mRNA.
DR EMBL; BC018132; AAH18132.1; -; mRNA.
DR EMBL; BC033299; AAH33299.1; -; mRNA.
DR CCDS; CCDS11493.1; -. [Q8WVC6-1]
DR RefSeq; NP_001122103.1; NM_001128631.2. [Q8WVC6-1]
DR RefSeq; NP_001275583.1; NM_001288654.2. [Q8WVC6-1]
DR RefSeq; NP_001275584.1; NM_001288655.1. [Q8WVC6-1]
DR RefSeq; NP_001308255.1; NM_001321326.1. [Q8WVC6-1]
DR RefSeq; NP_079095.3; NM_024819.6. [Q8WVC6-1]
DR RefSeq; XP_005257745.1; XM_005257688.2. [Q8WVC6-2]
DR RefSeq; XP_011523564.1; XM_011525262.2. [Q8WVC6-1]
DR RefSeq; XP_016880591.1; XM_017025102.1.
DR RefSeq; XP_016880592.1; XM_017025103.1. [Q8WVC6-2]
DR RefSeq; XP_016880593.1; XM_017025104.1. [Q8WVC6-2]
DR AlphaFoldDB; Q8WVC6; -.
DR SMR; Q8WVC6; -.
DR BioGRID; 122965; 86.
DR IntAct; Q8WVC6; 21.
DR MINT; Q8WVC6; -.
DR STRING; 9606.ENSP00000308515; -.
DR iPTMnet; Q8WVC6; -.
DR PhosphoSitePlus; Q8WVC6; -.
DR BioMuta; DCAKD; -.
DR DMDM; 74730834; -.
DR EPD; Q8WVC6; -.
DR jPOST; Q8WVC6; -.
DR MassIVE; Q8WVC6; -.
DR MaxQB; Q8WVC6; -.
DR PaxDb; Q8WVC6; -.
DR PeptideAtlas; Q8WVC6; -.
DR PRIDE; Q8WVC6; -.
DR ProteomicsDB; 74776; -. [Q8WVC6-1]
DR ProteomicsDB; 74777; -. [Q8WVC6-2]
DR Antibodypedia; 29945; 178 antibodies from 21 providers.
DR DNASU; 79877; -.
DR Ensembl; ENST00000310604.9; ENSP00000308515.5; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000342350.10; ENSP00000341504.4; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000452796.7; ENSP00000413483.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000588499.6; ENSP00000467913.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000592902.6; ENSP00000510000.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000651974.1; ENSP00000498268.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000684937.1; ENSP00000510351.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000684999.1; ENSP00000510563.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000685712.1; ENSP00000510250.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000685986.1; ENSP00000509434.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000687414.1; ENSP00000508598.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000687463.1; ENSP00000510527.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000687525.1; ENSP00000509864.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000687739.1; ENSP00000510018.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000687955.1; ENSP00000509609.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000688577.1; ENSP00000508805.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000688601.1; ENSP00000510526.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000688897.1; ENSP00000509802.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000689764.1; ENSP00000508534.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000690580.1; ENSP00000509278.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000691739.1; ENSP00000509762.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000692009.1; ENSP00000509683.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000692180.1; ENSP00000510227.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000692907.1; ENSP00000510095.1; ENSG00000172992.13. [Q8WVC6-2]
DR Ensembl; ENST00000693065.1; ENSP00000509729.1; ENSG00000172992.13. [Q8WVC6-1]
DR Ensembl; ENST00000693328.1; ENSP00000508491.1; ENSG00000172992.13. [Q8WVC6-2]
DR GeneID; 79877; -.
DR KEGG; hsa:79877; -.
DR MANE-Select; ENST00000651974.1; ENSP00000498268.1; NM_001288655.2; NP_001275584.1.
DR UCSC; uc002ihx.3; human. [Q8WVC6-1]
DR CTD; 79877; -.
DR GeneCards; DCAKD; -.
DR HGNC; HGNC:26238; DCAKD.
DR HPA; ENSG00000172992; Low tissue specificity.
DR neXtProt; NX_Q8WVC6; -.
DR OpenTargets; ENSG00000172992; -.
DR PharmGKB; PA142672013; -.
DR VEuPathDB; HostDB:ENSG00000172992; -.
DR eggNOG; KOG3220; Eukaryota.
DR GeneTree; ENSGT00550000075038; -.
DR InParanoid; Q8WVC6; -.
DR OMA; QMDIEQK; -.
DR OrthoDB; 1263008at2759; -.
DR PhylomeDB; Q8WVC6; -.
DR TreeFam; TF314815; -.
DR PathwayCommons; Q8WVC6; -.
DR SignaLink; Q8WVC6; -.
DR BioGRID-ORCS; 79877; 14 hits in 1088 CRISPR screens.
DR ChiTaRS; DCAKD; human.
DR GenomeRNAi; 79877; -.
DR Pharos; Q8WVC6; Tdark.
DR PRO; PR:Q8WVC6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8WVC6; protein.
DR Bgee; ENSG00000172992; Expressed in cortical plate and 139 other tissues.
DR ExpressionAtlas; Q8WVC6; baseline and differential.
DR Genevisible; Q8WVC6; HS.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IBA:GO_Central.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01121; CoaE; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00152; TIGR00152; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..231
FT /note="Dephospho-CoA kinase domain-containing protein"
FT /id="PRO_0000316849"
FT DOMAIN 3..207
FT /note="DPCK"
FT BINDING 8..15
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 106..132
FT /note="GYRYVILDIPLLFETKKLLKYMKHTVV -> EPRTSPRGKKHVPSALKEADS
FT LMRRDT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030810"
FT VAR_SEQ 133..231
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030811"
FT VARIANT 84
FT /note="N -> I (in dbSNP:rs17850104)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038406"
FT CONFLICT 218
FT /note="S -> N (in Ref. 1; BAF83444)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 26550 MW; E3AE93E8E3962544 CRC64;
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV EVFGTEVLLE
NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF KYFLRGYRYV ILDIPLLFET
KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL NRKDAEARIN AQLPLTDKAR MARHVLDNSG
EWSVTKRQVI LLHTELERSL EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A
