ID   DCAKD_MOUSE             Reviewed;         231 AA.
AC   Q8BHC4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Dephospho-CoA kinase domain-containing protein;
GN   Name=Dcakd;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Eye, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000305}.
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DR   EMBL; AK051022; BAC34499.1; -; mRNA.
DR   EMBL; AK078460; BAC37286.1; -; mRNA.
DR   EMBL; AK162069; BAE36709.1; -; mRNA.
DR   EMBL; AK170762; BAE42013.1; -; mRNA.
DR   EMBL; AL731670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC005607; AAH05607.1; -; mRNA.
DR   EMBL; BC045193; AAH45193.1; -; mRNA.
DR   CCDS; CCDS25510.1; -.
DR   RefSeq; NP_080827.2; NM_026551.3.
DR   RefSeq; XP_006534101.1; XM_006534038.2.
DR   AlphaFoldDB; Q8BHC4; -.
DR   SMR; Q8BHC4; -.
DR   BioGRID; 212648; 3.
DR   IntAct; Q8BHC4; 1.
DR   STRING; 10090.ENSMUSP00000021313; -.
DR   iPTMnet; Q8BHC4; -.
DR   PhosphoSitePlus; Q8BHC4; -.
DR   SwissPalm; Q8BHC4; -.
DR   EPD; Q8BHC4; -.
DR   jPOST; Q8BHC4; -.
DR   MaxQB; Q8BHC4; -.
DR   PaxDb; Q8BHC4; -.
DR   PeptideAtlas; Q8BHC4; -.
DR   PRIDE; Q8BHC4; -.
DR   ProteomicsDB; 279173; -.
DR   Antibodypedia; 29945; 178 antibodies from 21 providers.
DR   DNASU; 68087; -.
DR   Ensembl; ENSMUST00000021313; ENSMUSP00000021313; ENSMUSG00000020935.
DR   GeneID; 68087; -.
DR   KEGG; mmu:68087; -.
DR   UCSC; uc007ltc.1; mouse.
DR   CTD; 79877; -.
DR   MGI; MGI:1915337; Dcakd.
DR   VEuPathDB; HostDB:ENSMUSG00000020935; -.
DR   eggNOG; KOG3220; Eukaryota.
DR   GeneTree; ENSGT00550000075038; -.
DR   HOGENOM; CLU_057180_0_0_1; -.
DR   InParanoid; Q8BHC4; -.
DR   OMA; QMDIEQK; -.
DR   OrthoDB; 1263008at2759; -.
DR   PhylomeDB; Q8BHC4; -.
DR   TreeFam; TF314815; -.
DR   BioGRID-ORCS; 68087; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Dcakd; mouse.
DR   PRO; PR:Q8BHC4; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BHC4; protein.
DR   Bgee; ENSMUSG00000020935; Expressed in dorsal pancreas and 238 other tissues.
DR   ExpressionAtlas; Q8BHC4; baseline and differential.
DR   Genevisible; Q8BHC4; MM.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IBA:GO_Central.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01121; CoaE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00152; TIGR00152; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..231
FT                   /note="Dephospho-CoA kinase domain-containing protein"
FT                   /id="PRO_0000316850"
FT   DOMAIN          3..207
FT                   /note="DPCK"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  26476 MW;  32F4E938C5234B48 CRC64;
     MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVIARHVVQ PGYPAHRRIV EAFGTEVLLE
     NGDIDRKVLG DLIFNQPDRR QLLNSITHPE IRKEMMKETF KYFLRGYRYV ILDIPLLFET
     KKLLKYMKHT VVVYCDRDTQ LARLMKRNNL NREDAEARIN AQLPLKDKAR MANHVLDNSG
     EWSLTRRQAI LLHAKLERSM EYLPLRLGFL TGLAGIASLL YLLTRYLLPS P