DCBD2_MOUSE
ID DCBD2_MOUSE Reviewed; 769 AA.
AC Q91ZV3; A6X950; Q8BKI4;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Discoidin, CUB and LCCL domain-containing protein 2;
DE AltName: Full=Endothelial and smooth muscle cell-derived neuropilin-like protein;
DE Flags: Precursor;
GN Name=Dcbld2; Synonyms=Esdn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR;
RX PubMed=11447234; DOI=10.1074/jbc.m105293200;
RA Kobuke K., Furukawa Y., Sugai M., Tanigaki K., Ohashi N., Matsumori A.,
RA Sasayama S., Honjo T., Tashiro K.;
RT "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells
RT with the longest secretory signal sequence among eukaryotes, is up-
RT regulated after vascular injury.";
RL J. Biol. Chem. 276:34105-34114(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 168-769.
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; AF387548; AAL30179.1; -; mRNA.
DR EMBL; CT027564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066097; AAH66097.1; -; mRNA.
DR EMBL; AK051889; BAC34801.1; -; mRNA.
DR CCDS; CCDS28229.1; -.
DR RefSeq; NP_082799.2; NM_028523.3.
DR RefSeq; XP_006522685.1; XM_006522622.1.
DR AlphaFoldDB; Q91ZV3; -.
DR SMR; Q91ZV3; -.
DR BioGRID; 215971; 3.
DR STRING; 10090.ENSMUSP00000039915; -.
DR GlyGen; Q91ZV3; 5 sites.
DR iPTMnet; Q91ZV3; -.
DR PhosphoSitePlus; Q91ZV3; -.
DR MaxQB; Q91ZV3; -.
DR PaxDb; Q91ZV3; -.
DR PeptideAtlas; Q91ZV3; -.
DR PRIDE; Q91ZV3; -.
DR ProteomicsDB; 279884; -.
DR Antibodypedia; 8135; 211 antibodies from 29 providers.
DR DNASU; 73379; -.
DR Ensembl; ENSMUST00000046663; ENSMUSP00000039915; ENSMUSG00000035107.
DR GeneID; 73379; -.
DR KEGG; mmu:73379; -.
DR UCSC; uc007zno.1; mouse.
DR CTD; 131566; -.
DR MGI; MGI:1920629; Dcbld2.
DR VEuPathDB; HostDB:ENSMUSG00000035107; -.
DR eggNOG; ENOG502QRMB; Eukaryota.
DR GeneTree; ENSGT00940000158147; -.
DR HOGENOM; CLU_016654_2_0_1; -.
DR InParanoid; Q91ZV3; -.
DR OMA; GVGRTEI; -.
DR OrthoDB; 317808at2759; -.
DR PhylomeDB; Q91ZV3; -.
DR TreeFam; TF352191; -.
DR BioGRID-ORCS; 73379; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Dcbld2; mouse.
DR PRO; PR:Q91ZV3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q91ZV3; protein.
DR Bgee; ENSMUSG00000035107; Expressed in decidua and 218 other tissues.
DR Genevisible; Q91ZV3; MM.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0042060; P:wound healing; ISS:UniProtKB.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.170.130.20; -; 1.
DR Gene3D; 2.60.120.290; -; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF03815; LCCL; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00603; LCCL; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
DR SUPFAM; SSF69848; SSF69848; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50820; LCCL; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..63
FT /evidence="ECO:0000255"
FT CHAIN 64..769
FT /note="Discoidin, CUB and LCCL domain-containing protein 2"
FT /id="PRO_0000021079"
FT TOPO_DOM 64..523
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 545..769
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 69..184
FT /note="CUB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 184..282
FT /note="LCCL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT DOMAIN 289..446
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 601
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PD2"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 511
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 69..96
FT /evidence="ECO:0000250"
FT DISULFID 123..145
FT /evidence="ECO:0000250"
FT DISULFID 212..234
FT /evidence="ECO:0000250"
FT DISULFID 289..446
FT /evidence="ECO:0000250"
FT CONFLICT 478..479
FT /note="Missing (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 769 AA; 83774 MW; 73C1F1646FA3F017 CRC64;
MASRAPLRAA RSPQGPGGPA APAATGRAAL PSAGCCPLPP GRNSSSRPRL LLLLLLLLQD
AGGQQGDGCG HTVLGPESGT LTSINYPHTY PNSTVCEWEI RVRTGERIRI KFGDFDIEDS
DYCHLNYLKI FNGIGVSRTE IGKYCGLGLQ MNQSIESKGS EVTVLFMSGT HAAGRGFLAS
YSVIDKEDLI TCLDTVSNFL EPEFSKYCPA GCLLPFAEIS GTIPHGYRDS SPLCMAGIHA
GVVSNVLGGQ ISIVISKGTP YYESSLANNV TSTVGYLSAS LFTFKTSGCY GTLGMESGVI
ADPQITASSA LEWTDHMGQE NSWTAEKARL RKPGPPWAAF ATDEHQWLQI DLNKEKKITG
IVTTGSTMIE HSYYVSAYRV LYSDDGQRWT VYREPGVDQD KIFQGNKDYH KDVRNNFLPP
IIARFIRVNP VQWQQKIAMK VELLGCQFTL KGRLPKLTPP PRNGNNLRNT TARPKLGKGR
APKFTQVLQP RSRNELPVQP AETTTTPDIK NTTVTPSVTK DVALAAVLVP VLVMALTTLI
LILVCAWHWR NRKKKTEGAY DLPHWDRAGW WKGMKQLLPA KSVDHEETPV RYSTSEVSHL
SAREVTTVLQ ADSAEYAQPL VGGIVGTLHQ RSTFKPEEGK EAGYADLDPY NSPMQEVYHA
YAEPLPVTGP EYATPIVMDM SGHPTASVGL PSTSTFKTAG TQPHALVGTY NTLLSRTDSC
SSGQAQYDTP KGGKSAATPE ELVYQVPQST QELSGAGRDE KFDAFKEIL
