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DCBD2_RAT
ID   DCBD2_RAT               Reviewed;         769 AA.
AC   Q91ZV2;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Discoidin, CUB and LCCL domain-containing protein 2;
DE   AltName: Full=Endothelial and smooth muscle cell-derived neuropilin-like protein;
DE   Flags: Precursor;
GN   Name=Dcbld2; Synonyms=Esdn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11447234; DOI=10.1074/jbc.m105293200;
RA   Kobuke K., Furukawa Y., Sugai M., Tanigaki K., Ohashi N., Matsumori A.,
RA   Sasayama S., Honjo T., Tashiro K.;
RT   "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells
RT   with the longest secretory signal sequence among eukaryotes, is up-
RT   regulated after vascular injury.";
RL   J. Biol. Chem. 276:34105-34114(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AF387549; AAL30180.1; -; mRNA.
DR   RefSeq; NP_569103.1; NM_130419.1.
DR   AlphaFoldDB; Q91ZV2; -.
DR   SMR; Q91ZV2; -.
DR   STRING; 10116.ENSRNOP00000002251; -.
DR   GlyGen; Q91ZV2; 5 sites.
DR   PaxDb; Q91ZV2; -.
DR   PRIDE; Q91ZV2; -.
DR   GeneID; 155696; -.
DR   KEGG; rno:155696; -.
DR   UCSC; RGD:620543; rat.
DR   CTD; 131566; -.
DR   RGD; 620543; Dcbld2.
DR   eggNOG; ENOG502QRMB; Eukaryota.
DR   InParanoid; Q91ZV2; -.
DR   OrthoDB; 317808at2759; -.
DR   PhylomeDB; Q91ZV2; -.
DR   PRO; PR:Q91ZV2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0042060; P:wound healing; ISS:UniProtKB.
DR   CDD; cd00041; CUB; 1.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.170.130.20; -; 1.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF03815; LCCL; 1.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00603; LCCL; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
DR   SUPFAM; SSF69848; SSF69848; 1.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS50820; LCCL; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..63
FT                   /evidence="ECO:0000255"
FT   CHAIN           64..769
FT                   /note="Discoidin, CUB and LCCL domain-containing protein 2"
FT                   /id="PRO_0000021080"
FT   TOPO_DOM        64..523
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        524..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        545..769
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          69..184
FT                   /note="CUB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DOMAIN          184..282
FT                   /note="LCCL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DOMAIN          289..446
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         601
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96PD2"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        471
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        511
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        69..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        123..145
FT                   /evidence="ECO:0000250"
FT   DISULFID        212..234
FT                   /evidence="ECO:0000250"
FT   DISULFID        289..446
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   769 AA;  83915 MW;  5B7936C8FA063A93 CRC64;
     MASRAPLRAA RSPQDPGGRA APAATGRAPL PSAGWCPLPP GRNSSSRPRL LLLLLLLLPD
     AGAQKGDGCG HTVLGPESGT LTSINYPHTY PNSTVCKWEI RVKTGERIRI KFGDFDIEDS
     DYCHLNYLKI FNGIGVSRTE IGKYCGLGLQ MNQSIESKGS EITVLFMSGI HASGRGFLAS
     YSVIDKQDLI TCLDTVSNFL EPEFSKYCPA GCLLPFAEIS GTIPHGYRDS SPLCMAGIHA
     GVVSDVLGGQ ISVVISKGTP YYESSLANNV TSMVGYLSTS LFTFKTSGCY GTLGMESGVI
     ADPQITASSV LEWTDHMGQE NSWKPEKARL RKPGPPWAAF ATDEHQWLQI DLNKEKKITG
     IVTTGSTLIE HNYYVSAYRV LYSDDGQKWT VYREPGAAQD KIFQGNKDYH KDVRNNFLPP
     IIARFIRVNP VQWQQKIAMK VELLGCQFTL KGRLPKLTQP PPPRNSNNLK NTTVHPKLGR
     APKFTQALQP RSRNDLPLLP AQTTATPDVK NTTVTPSVTK DVALAAVLVP VLVMALTTLI
     LILVCAWHWR NRKKKAEGTY DLPHWDRAGW WKGVKQLLPA KSVEHEETPV RYSNSEVSHL
     SPREVTTVLQ ADSAEYAQPL VGGIVGTLHQ RSTFKPEEGK EASYADLDPY NAPVQEVYHA
     YAEPLPVTGP EYATPIVMDM SGHSTASVGL PSTSTFRTAG NQPPALVGTY NTLLSRTDSC
     SSGQAQYDTP KGGKPAAAPE ELVYQVPQST QEASGAGRDE KFDAFKETL
 
 
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