ID   DCC1_DANRE              Reviewed;         391 AA.
AC   Q66I84;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Sister chromatid cohesion protein DCC1;
DE   AltName: Full=Defective in sister chromatid cohesion protein 1 homolog;
GN   Name=dscc1; Synonyms=dcc1; ORFNames=zgc:103507;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Loads pcna onto primed templates regulating velocity, spacing
CC       and restart activity of replication forks. May couple DNA replication
CC       to sister chromatid cohesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ctf18-RFC complex which consists of ctf18,
CC       ctf8, dscc1 and the RFC complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DCC1 family. {ECO:0000305}.
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DR   EMBL; BC081483; AAH81483.1; -; mRNA.
DR   RefSeq; NP_001004611.1; NM_001004611.1.
DR   AlphaFoldDB; Q66I84; -.
DR   SMR; Q66I84; -.
DR   STRING; 7955.ENSDARP00000025936; -.
DR   PaxDb; Q66I84; -.
DR   GeneID; 447872; -.
DR   KEGG; dre:447872; -.
DR   CTD; 79075; -.
DR   ZFIN; ZDB-GENE-040912-35; dscc1.
DR   eggNOG; KOG0798; Eukaryota.
DR   InParanoid; Q66I84; -.
DR   OrthoDB; 1140219at2759; -.
DR   PhylomeDB; Q66I84; -.
DR   Reactome; R-DRE-174411; Polymerase switching on the C-strand of the telomere.
DR   PRO; PR:Q66I84; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   GO; GO:0006275; P:regulation of DNA replication; ISS:UniProtKB.
DR   InterPro; IPR019128; Dcc1.
DR   PANTHER; PTHR13395; PTHR13395; 1.
DR   Pfam; PF09724; Dcc1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..391
FT                   /note="Sister chromatid cohesion protein DCC1"
FT                   /id="PRO_0000318066"
SQ   SEQUENCE   391 AA;  44656 MW;  213A7294095B55B2 CRC64;
     MRTLEEVQGT LQIAKVKEED LQPVTYCLSF GDNVSSGDYC LMEVDENLCK HIESGKSLII
     RGDKDEHAVL CSEDKTYDLK IADTSNLLLF VPGCKTPDQL SDIPASPQLM HTQIWGFSNC
     YWELRRQRPR LKKLKKLLME NPYDGPPVGM QEEAPGLKYS MEDLLERIQA SKEELEAHLG
     NVHACEIDGF WRILDFDYEM KLLGHVTQLV DSESWSFSKV PLSVCLEELG SLEPKAMIEH
     CLNCYGRRHS DEDNQVMYAL DEDKVCRATA QLLLQNAVKF NLSEFQEVWQ QSVPEGMGTR
     LDQLRGLALI DRSSKPETIS LLRVEDLPED TLERFNSLFS LREKWTQDDI EPYIQDLCGE
     KQTTGALLTK HARSSMQNGI KVYNSRRPVA T