ID   DCC1_MOUSE              Reviewed;         399 AA.
AC   Q14AI0; Q4FZL5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Sister chromatid cohesion protein DCC1;
DE   AltName: Full=Defective in sister chromatid cohesion protein 1 homolog;
GN   Name=DSCC1; Synonyms=DCC1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Oocyte;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Loads PCNA onto primed templates regulating velocity, spacing
CC       and restart activity of replication forks. May couple DNA replication
CC       to sister chromatid cohesion through regulation of the acetylation of
CC       the cohesin subunit SMC3 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CTF18-RFC complex which consists of CTF8,
CC       CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18.
CC       Interacts with DDX11. {ECO:0000250|UniProtKB:Q9BVC3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DCC1 family. {ECO:0000305}.
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DR   EMBL; BC099382; AAH99382.1; -; mRNA.
DR   EMBL; BC116833; AAI16834.1; -; mRNA.
DR   EMBL; BC116835; AAI16836.1; -; mRNA.
DR   CCDS; CCDS27473.1; -.
DR   RefSeq; NP_898912.2; NM_183089.2.
DR   AlphaFoldDB; Q14AI0; -.
DR   SMR; Q14AI0; -.
DR   STRING; 10090.ENSMUSP00000023059; -.
DR   PhosphoSitePlus; Q14AI0; -.
DR   EPD; Q14AI0; -.
DR   MaxQB; Q14AI0; -.
DR   PaxDb; Q14AI0; -.
DR   PRIDE; Q14AI0; -.
DR   ProteomicsDB; 279161; -.
DR   Antibodypedia; 26822; 209 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
DR   GeneID; 72107; -.
DR   KEGG; mmu:72107; -.
DR   UCSC; uc007vrw.1; mouse.
DR   CTD; 79075; -.
DR   MGI; MGI:1919357; Dscc1.
DR   VEuPathDB; HostDB:ENSMUSG00000022422; -.
DR   eggNOG; KOG0798; Eukaryota.
DR   GeneTree; ENSGT00390000017400; -.
DR   InParanoid; Q14AI0; -.
DR   OMA; YVRTPED; -.
DR   OrthoDB; 1140219at2759; -.
DR   PhylomeDB; Q14AI0; -.
DR   TreeFam; TF106104; -.
DR   Reactome; R-MMU-174411; Polymerase switching on the C-strand of the telomere.
DR   BioGRID-ORCS; 72107; 17 hits in 73 CRISPR screens.
DR   PRO; PR:Q14AI0; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q14AI0; protein.
DR   Bgee; ENSMUSG00000022422; Expressed in manus and 136 other tissues.
DR   ExpressionAtlas; Q14AI0; baseline and differential.
DR   Genevisible; Q14AI0; MM.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; ISO:MGI.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003689; F:DNA clamp loader activity; ISO:MGI.
DR   GO; GO:0017116; F:single-stranded DNA helicase activity; ISO:MGI.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; ISS:UniProtKB.
DR   GO; GO:0034421; P:post-translational protein acetylation; ISS:UniProtKB.
DR   GO; GO:0006275; P:regulation of DNA replication; ISS:UniProtKB.
DR   InterPro; IPR019128; Dcc1.
DR   PANTHER; PTHR13395; PTHR13395; 1.
DR   Pfam; PF09724; Dcc1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..399
FT                   /note="Sister chromatid cohesion protein DCC1"
FT                   /id="PRO_0000318065"
SQ   SEQUENCE   399 AA;  45522 MW;  7AF16514EF64D9E5 CRC64;
     MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC LLELEPALCQ
     QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF IPGCKTPDQL KEEETPSAIV
     HTEIFGFSNN YWELRRCRPK LKKLKRLLME NTYEGPDSQK EEDASRSKYT TEDLLNHIQA
     SEEEIMAQLQ VLNACEIGGY WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG
     PLEPEEMIEH CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ
     SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL REKWTEEDIT
     PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS