ID   DCC1_SCHPO              Reviewed;         357 AA.
AC   Q09732;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Sister chromatid cohesion protein dcc1;
DE   AltName: Full=Defective in sister chromatid cohesion protein 1;
GN   Name=dcc1; ORFNames=SPAC31A2.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   FUNCTION.
RX   PubMed=15226378; DOI=10.1242/jcs.01231;
RA   Petronczki M., Chwalla B., Siomos M.F., Yokobayashi S., Helmhart W.,
RA   Deutschbauer A.M., Davis R.W., Watanabe Y., Nasmyth K.;
RT   "Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8,
RT   the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is
RT   essential for chromatid disjunction during meiosis II.";
RL   J. Cell Sci. 117:3547-3559(2004).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Essential for the fidelity of chromosome transmission.
CC       Required for the DNA replication block checkpoint. Replication factor C
CC       (RFC) complex has an essential but redundant activity in sister
CC       chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is
CC       formed where ctf18 replaces rfc1 in the RFC complex along with the
CC       association of dcc1 and ctf8. This complex is required for efficient
CC       establishment of chromosome cohesion during S-phase. Acts as a PCNA
CC       loader, loading PCNA onto primed templates.
CC       {ECO:0000269|PubMed:15226378}.
CC   -!- SUBUNIT: Component of the ctf18-RFC complex which consists of ctf18,
CC       ctf8, dcc1, rfc2, rfc3, rfc4 and rfc5. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the DCC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAA90473.2; -; Genomic_DNA.
DR   PIR; T38613; S59648.
DR   RefSeq; NP_592927.2; NM_001018328.2.
DR   AlphaFoldDB; Q09732; -.
DR   SMR; Q09732; -.
DR   BioGRID; 279511; 68.
DR   STRING; 4896.SPAC31A2.15c.1; -.
DR   iPTMnet; Q09732; -.
DR   MaxQB; Q09732; -.
DR   PaxDb; Q09732; -.
DR   PRIDE; Q09732; -.
DR   EnsemblFungi; SPAC31A2.15c.1; SPAC31A2.15c.1:pep; SPAC31A2.15c.
DR   GeneID; 2543078; -.
DR   KEGG; spo:SPAC31A2.15c; -.
DR   PomBase; SPAC31A2.15c; dcc1.
DR   VEuPathDB; FungiDB:SPAC31A2.15c; -.
DR   eggNOG; KOG0798; Eukaryota.
DR   HOGENOM; CLU_034504_0_0_1; -.
DR   InParanoid; Q09732; -.
DR   OMA; KISYWDE; -.
DR   PRO; PR:Q09732; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; ISO:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IBA:GO_Central.
DR   InterPro; IPR019128; Dcc1.
DR   PANTHER; PTHR13395; PTHR13395; 1.
DR   Pfam; PF09724; Dcc1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..357
FT                   /note="Sister chromatid cohesion protein dcc1"
FT                   /id="PRO_0000116394"
SQ   SEQUENCE   357 AA;  41954 MW;  FA05D271D59F0EB9 CRC64;
     MEANEERCIL LKYPHPSSDI SSEYLLLELD DDLLKTLEEN PEEEIVFKSD FDKKASVLCT
     SDKTYAVRQV VQSNSYLLFD ELSPTDWVLN DTCYSFLEVE RIYGFIFSDD KISYWDEDSV
     ELKPISLTKD QFIRSVPASR NEVDSFLQKN FFMVKNEFLY RLSPSYICSI IDWIFVIAQQ
     LHIDFASFEF KILKKPAMDD EFDWDSVICV LESISSPIKD NVLPKKFNID LELTTFWYGR
     FLLEGINSIS SDEFIQLWDN RLPYPCKGLP SLNLLKGYYF HDTPNTIQYL SGDQLPREPS
     RRFQSLFQLK SKWLYEELWS FVKDLALSKS RVEALILKYG RKQTSRDGVY INSRGTW