ID   DCC1_XENTR              Reviewed;         391 AA.
AC   Q6GL75;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Sister chromatid cohesion protein DCC1;
GN   Name=dscc1; Synonyms=dcc1; ORFNames=TNeu038i11.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Loads pcna onto primed templates regulating velocity, spacing
CC       and restart activity of replication forks. May couple DNA replication
CC       to sister chromatid cohesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ctf18-RFC complex which consists of ctf18,
CC       ctf8, dscc1 and the RFC complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DCC1 family. {ECO:0000305}.
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DR   EMBL; CR760288; CAJ83021.1; -; mRNA.
DR   EMBL; BC074630; AAH74630.1; -; mRNA.
DR   RefSeq; NP_001004834.1; NM_001004834.1.
DR   AlphaFoldDB; Q6GL75; -.
DR   SMR; Q6GL75; -.
DR   STRING; 8364.ENSXETP00000006777; -.
DR   PaxDb; Q6GL75; -.
DR   DNASU; 448100; -.
DR   GeneID; 448100; -.
DR   KEGG; xtr:448100; -.
DR   CTD; 79075; -.
DR   Xenbase; XB-GENE-5781750; dscc1.
DR   eggNOG; KOG0798; Eukaryota.
DR   HOGENOM; CLU_034504_1_1_1; -.
DR   InParanoid; Q6GL75; -.
DR   OrthoDB; 1140219at2759; -.
DR   Reactome; R-XTR-174411; Polymerase switching on the C-strand of the telomere.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003126; Expressed in ovary and 15 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   GO; GO:0006275; P:regulation of DNA replication; ISS:UniProtKB.
DR   InterPro; IPR019128; Dcc1.
DR   PANTHER; PTHR13395; PTHR13395; 1.
DR   Pfam; PF09724; Dcc1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..391
FT                   /note="Sister chromatid cohesion protein DCC1"
FT                   /id="PRO_0000318068"
SQ   SEQUENCE   391 AA;  44632 MW;  08552100154E9DB3 CRC64;
     MSRSAEEVEA TLQIAKVDLE DLRNTVHCLT FSSDFTSGDY SLMELDDTLC KQIEAGDSLV
     IRGDKSDHAV LCSQDKTYDL KIADTSNLLL FIPGCKTPDQ LPADQQPLTI INCEIAGFSN
     HYWELRRCRP KLKKLKKLLM ENTYNGPENE RESQDNSLHT TEDLLNMIQA SNEELVDHLK
     AIHACSINGF WRLLDFDYEM KLLNHITQLI DSESWSFSKV PLPVCLQELR SLEPEEMIEH
     CLTCYGKRLI DEGTGGDFFA LDEDKICRAT ALMLLQNAVK FNLAEFQEVW QQSVPEGMNT
     RLDQLKGLAL VDRTSRPETI FLLKTEDLPE DTQERFNTLF GMREKWAEAD IAPYIKDLCG
     EKQTIGALLT KYARSSMQNG IKLYNSRRPL S