ID   DCD1B_DICDI             Reviewed;         500 AA.
AC   Q54CS6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein dcd1B;
DE   AltName: Full=Acid ceramidase-like protein B;
DE   Flags: Precursor;
GN   Name=dcd1B; ORFNames=DDB_G0292768;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA   Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA   Ivens A., Martinez J.L., Escalante R.;
RT   "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT   and specific effects from PAO1 and PA14 strains.";
RL   BMC Microbiol. 8:109-109(2008).
RN   [3]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA   Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT   bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain and
CC       PA14 strain infection and down-regulated by phagocytic stimuli.
CC       {ECO:0000269|PubMed:18559084, ECO:0000269|PubMed:18590548}.
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DR   EMBL; AAFI02000196; EAL61058.1; -; Genomic_DNA.
DR   RefSeq; XP_629465.1; XM_629463.1.
DR   AlphaFoldDB; Q54CS6; -.
DR   SMR; Q54CS6; -.
DR   PaxDb; Q54CS6; -.
DR   EnsemblProtists; EAL61058; EAL61058; DDB_G0292768.
DR   GeneID; 8628855; -.
DR   KEGG; ddi:DDB_G0292768; -.
DR   dictyBase; DDB_G0292768; dcd1B.
DR   eggNOG; ENOG502RA4J; Eukaryota.
DR   HOGENOM; CLU_616695_0_0_1; -.
DR   InParanoid; Q54CS6; -.
DR   OMA; HMFPELV; -.
DR   PhylomeDB; Q54CS6; -.
DR   PRO; PR:Q54CS6; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..500
FT                   /note="Protein dcd1B"
FT                   /id="PRO_0000384456"
FT   REGION          464..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        331
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        441
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        459
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        474
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        475
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   500 AA;  55725 MW;  1DEF3A3166E9EF44 CRC64;
     MNLIKLFIIC CLLISITVKS FEIENDIDID FEFDNSFDQS SSSAGSGSDS YDQDKCKGKP
     NPYPIFNKEP IFIASTANGK LYKTGDDSNQ VSILHLYGEA YEMGYAHGTL LKEQVNELIP
     KFMEFAEIAI KEFIKTKFAL RLPEFLIKLI EEFGVNAALD YVASATEQFT PKRFFNELLG
     LSDSSGIPYQ TLLRMHMFPE LVKATCSIVG AWSEATINGG LLQVRALDWG LENPLVNYPT
     LIVYHPQEND GGEFSILSWT SFIGALTGYS QRTGVCEKVW LSYNGTYTHN GMPFYFILRD
     ILQYDNSIYE ALNRIYNTPR TCAVYLGVGS NESNTASLLE VSMDVVRVFD DETPFPGFAP
     PVPEHPLFKD VVYVDKHSQP STDPCMANSL SQSWSEITAQ TLINTMGQME TGDLHSAVYD
     FKQNLVYVSV ATTNIPFPFT NETLPLVSPA YKNQFIQFNM TKLFSEQPPL PPPNNSSSSD
     SNSNSNSDSS SSSDSNSNSN