DCD2B_HUMAN
ID DCD2B_HUMAN Reviewed; 349 AA.
AC A2VCK2; B7ZBC6;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Doublecortin domain-containing protein 2B;
GN Name=DCDC2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A2VCK2; Q8N9N5: BANP; NbExp=3; IntAct=EBI-10173222, EBI-744695;
CC A2VCK2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10173222, EBI-3867333;
CC A2VCK2; Q13643: FHL3; NbExp=6; IntAct=EBI-10173222, EBI-741101;
CC A2VCK2; Q5TD97: FHL5; NbExp=3; IntAct=EBI-10173222, EBI-750641;
CC A2VCK2; O43559: FRS3; NbExp=3; IntAct=EBI-10173222, EBI-725515;
CC A2VCK2; O75031: HSF2BP; NbExp=3; IntAct=EBI-10173222, EBI-7116203;
CC A2VCK2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10173222, EBI-10171697;
CC A2VCK2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10173222, EBI-3957694;
CC A2VCK2; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10173222, EBI-742948;
CC A2VCK2; Q93062: RBPMS; NbExp=3; IntAct=EBI-10173222, EBI-740322;
CC A2VCK2; Q6ZN55-2: ZNF574; NbExp=3; IntAct=EBI-10173222, EBI-17189720;
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DR EMBL; AL049795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128073; AAI28074.1; -; mRNA.
DR CCDS; CCDS44100.1; -.
DR RefSeq; NP_001092904.1; NM_001099434.1.
DR AlphaFoldDB; A2VCK2; -.
DR SMR; A2VCK2; -.
DR BioGRID; 127189; 21.
DR IntAct; A2VCK2; 19.
DR STRING; 9606.ENSP00000386870; -.
DR iPTMnet; A2VCK2; -.
DR PhosphoSitePlus; A2VCK2; -.
DR BioMuta; DCDC2B; -.
DR MassIVE; A2VCK2; -.
DR PaxDb; A2VCK2; -.
DR PeptideAtlas; A2VCK2; -.
DR PRIDE; A2VCK2; -.
DR ProteomicsDB; 529; -.
DR Antibodypedia; 52447; 33 antibodies from 14 providers.
DR DNASU; 149069; -.
DR Ensembl; ENST00000409358.2; ENSP00000386870.1; ENSG00000222046.3.
DR GeneID; 149069; -.
DR KEGG; hsa:149069; -.
DR MANE-Select; ENST00000409358.2; ENSP00000386870.1; NM_001099434.2; NP_001092904.1.
DR UCSC; uc001bun.2; human.
DR CTD; 149069; -.
DR GeneCards; DCDC2B; -.
DR HGNC; HGNC:32576; DCDC2B.
DR HPA; ENSG00000222046; Tissue enriched (fallopian).
DR neXtProt; NX_A2VCK2; -.
DR OpenTargets; ENSG00000222046; -.
DR PharmGKB; PA145008541; -.
DR VEuPathDB; HostDB:ENSG00000222046; -.
DR eggNOG; KOG3757; Eukaryota.
DR GeneTree; ENSGT00940000161946; -.
DR HOGENOM; CLU_035041_0_1_1; -.
DR InParanoid; A2VCK2; -.
DR OMA; FHKLHYL; -.
DR OrthoDB; 894392at2759; -.
DR PhylomeDB; A2VCK2; -.
DR TreeFam; TF338406; -.
DR PathwayCommons; A2VCK2; -.
DR SignaLink; A2VCK2; -.
DR BioGRID-ORCS; 149069; 18 hits in 1068 CRISPR screens.
DR GenomeRNAi; 149069; -.
DR Pharos; A2VCK2; Tdark.
DR PRO; PR:A2VCK2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A2VCK2; protein.
DR Bgee; ENSG00000222046; Expressed in right uterine tube and 133 other tissues.
DR Genevisible; A2VCK2; HS.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.10.20.230; -; 2.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR Pfam; PF03607; DCX; 2.
DR SMART; SM00537; DCX; 2.
DR SUPFAM; SSF89837; SSF89837; 2.
DR PROSITE; PS50309; DC; 2.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat.
FT CHAIN 1..349
FT /note="Doublecortin domain-containing protein 2B"
FT /id="PRO_0000305008"
FT DOMAIN 9..91
FT /note="Doublecortin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 129..211
FT /note="Doublecortin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT REGION 222..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 37665 MW; 57BBA0506F10F3F0 CRC64;
MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP LAVRALYTPC
HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG KSCRLQGPPV TRHLCDGAIG
RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ AASQDWETVL KLLTEKVKLQ SGAVCKLCTL
EGLPLSAGKE LVTGHYYVAV GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ
GHRAQVTQPS PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG
ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS
