ID   DCD2C_HUMAN             Reviewed;         364 AA.
AC   A8MYV0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2019, sequence version 4.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Doublecortin domain-containing protein 2C {ECO:0000305};
GN   Name=DCDC2C {ECO:0000312|HGNC:HGNC:32696};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=28395323; DOI=10.1095/biolreprod.116.143479;
RA   Jumeau F., Chalmel F., Fernandez-Gomez F.J., Carpentier C., Obriot H.,
RA   Tardivel M., Caillet-Boudin M.L., Rigot J.M., Rives N., Buee L.,
RA   Sergeant N., Mitchell V.;
RT   "Defining the human sperm microtubulome: an integrated genomics approach.";
RL   Biol. Reprod. 96:93-106(2017).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:28395323}. Cytoplasm {ECO:0000269|PubMed:28395323}.
CC       Note=Detected along the length of the sperm flagellum and in the
CC       cytoplasm of the germ cells. {ECO:0000269|PubMed:28395323}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis and spermatozoa (at protein
CC       level). {ECO:0000269|PubMed:28395323}.
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DR   EMBL; AC010907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS74481.1; -.
DR   RefSeq; NP_001274373.1; NM_001287444.1.
DR   AlphaFoldDB; A8MYV0; -.
DR   SMR; A8MYV0; -.
DR   STRING; 9606.ENSP00000382097; -.
DR   iPTMnet; A8MYV0; -.
DR   PhosphoSitePlus; A8MYV0; -.
DR   BioMuta; DCDC2C; -.
DR   MassIVE; A8MYV0; -.
DR   PaxDb; A8MYV0; -.
DR   PeptideAtlas; A8MYV0; -.
DR   PRIDE; A8MYV0; -.
DR   ProteomicsDB; 2428; -.
DR   Antibodypedia; 50948; 7 antibodies from 6 providers.
DR   DNASU; 728597; -.
DR   Ensembl; ENST00000399143.9; ENSP00000382097.4; ENSG00000214866.9.
DR   GeneID; 728597; -.
DR   KEGG; hsa:728597; -.
DR   MANE-Select; ENST00000399143.9; ENSP00000382097.4; NM_001287444.2; NP_001274373.1.
DR   UCSC; uc032nde.2; human.
DR   CTD; 728597; -.
DR   DisGeNET; 728597; -.
DR   GeneCards; DCDC2C; -.
DR   HGNC; HGNC:32696; DCDC2C.
DR   HPA; ENSG00000214866; Tissue enriched (testis).
DR   neXtProt; NX_A8MYV0; -.
DR   OpenTargets; ENSG00000214866; -.
DR   VEuPathDB; HostDB:ENSG00000214866; -.
DR   eggNOG; KOG3757; Eukaryota.
DR   GeneTree; ENSGT00940000162396; -.
DR   InParanoid; A8MYV0; -.
DR   OMA; CKYDGIP; -.
DR   PhylomeDB; A8MYV0; -.
DR   SignaLink; A8MYV0; -.
DR   ChiTaRS; DCDC2C; human.
DR   Pharos; A8MYV0; Tdark.
DR   PRO; PR:A8MYV0; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A8MYV0; protein.
DR   Bgee; ENSG00000214866; Expressed in sural nerve and 79 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.10.20.230; -; 2.
DR   InterPro; IPR003533; Doublecortin_dom.
DR   InterPro; IPR036572; Doublecortin_dom_sf.
DR   Pfam; PF03607; DCX; 2.
DR   SMART; SM00537; DCX; 2.
DR   SUPFAM; SSF89837; SSF89837; 2.
DR   PROSITE; PS50309; DC; 2.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Flagellum; Reference proteome; Repeat.
FT   CHAIN           1..364
FT                   /note="Doublecortin domain-containing protein 2C"
FT                   /id="PRO_0000344449"
FT   DOMAIN          16..98
FT                   /note="Doublecortin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT   DOMAIN          136..217
FT                   /note="Doublecortin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT   REGION          233..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..255
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  41608 MW;  4987BCC4CFB9BC93 CRC64;
     MGTRGPSAPV DTTPAKTIVV YRNGDPFYVG KKFVLSRRRA ATFEALLEQL TEQVDVPFGV
     RRLFTPTRGH RVLGLDALQA GGKYVAAGRE RFKELDYIHI VPRKPAKIRK LKEIKPVVHC
     DINVPSKWQT YHRISRHINV FTNGRLFIPP AKIIIPKFSL SDWDIVLATI GEKVFPLGGV
     RKLFTMNGHL LGDSKDLQDN HFYVAVGLET FKYFPYWKSP RVPSEVQQRY ANVEKNSQRK
     KKVDSKGKEP CKYDGIPPKT QDSVYYAKEE KKKTLAEPLV QRGAEGDVYK APTPSKETQG
     ALDVKEEHNV QLEVPVDQRQ AEIVKEDEEI HENTPDFEGN KDKEDARLCE DVERKMAREW
     KPVD