DCD2C_MOUSE
ID DCD2C_MOUSE Reviewed; 347 AA.
AC Q9D1B8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Doublecortin domain-containing protein 2C {ECO:0000305};
GN Name=Dcdc2c {ECO:0000312|MGI:MGI:1915761};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A8MYV0}. Cytoplasm
CC {ECO:0000250|UniProtKB:A8MYV0}. Note=Detected along the length of the
CC sperm flagellum and in the cytoplasm of the germ cells.
CC {ECO:0000250|UniProtKB:A8MYV0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D1B8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D1B8-2; Sequence=VSP_040534;
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DR EMBL; AK003729; BAB22964.1; -; mRNA.
DR EMBL; AC165283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS79109.1; -. [Q9D1B8-2]
DR RefSeq; NP_001171435.2; NM_001177964.2. [Q9D1B8-2]
DR AlphaFoldDB; Q9D1B8; -.
DR SMR; Q9D1B8; -.
DR STRING; 10090.ENSMUSP00000020963; -.
DR PhosphoSitePlus; Q9D1B8; -.
DR PaxDb; Q9D1B8; -.
DR PRIDE; Q9D1B8; -.
DR ProteomicsDB; 277964; -. [Q9D1B8-1]
DR ProteomicsDB; 277965; -. [Q9D1B8-2]
DR Antibodypedia; 50948; 7 antibodies from 6 providers.
DR Ensembl; ENSMUST00000189735; ENSMUSP00000140603; ENSMUSG00000020633. [Q9D1B8-2]
DR GeneID; 68511; -.
DR KEGG; mmu:68511; -.
DR UCSC; uc007nfo.1; mouse. [Q9D1B8-1]
DR CTD; 728597; -.
DR MGI; MGI:1915761; Dcdc2c.
DR VEuPathDB; HostDB:ENSMUSG00000020633; -.
DR eggNOG; KOG3757; Eukaryota.
DR GeneTree; ENSGT00940000162396; -.
DR HOGENOM; CLU_126324_0_0_1; -.
DR InParanoid; Q9D1B8; -.
DR OrthoDB; 894392at2759; -.
DR PhylomeDB; Q9D1B8; -.
DR BioGRID-ORCS; 68511; 3 hits in 65 CRISPR screens.
DR PRO; PR:Q9D1B8; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D1B8; protein.
DR Bgee; ENSMUSG00000020633; Expressed in spermatid and 29 other tissues.
DR ExpressionAtlas; Q9D1B8; baseline and differential.
DR Genevisible; Q9D1B8; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.10.20.230; -; 2.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR Pfam; PF03607; DCX; 2.
DR SMART; SM00537; DCX; 2.
DR SUPFAM; SSF89837; SSF89837; 2.
DR PROSITE; PS50309; DC; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Cytoplasm; Flagellum;
KW Reference proteome; Repeat.
FT CHAIN 1..347
FT /note="Doublecortin domain-containing protein 2C"
FT /id="PRO_0000344450"
FT DOMAIN 16..98
FT /note="Doublecortin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 136..217
FT /note="Doublecortin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT REGION 235..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..168
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040534"
SQ SEQUENCE 347 AA; 39355 MW; 650E959CE82CE4DB CRC64;
MGTRGPYALV DTTPAKTILV YRNGDQFYVG RKFVFSRRRV ANFEALLEQL TEQVEVPFGV
RRLYTPTRGH PVLGLDALQT GGKYVAAGRE RFKKLDYIHI VPRKPSKMRK LKEIKPVVHC
DIKVPSRWQI QSRTSRYINV FTNGRLFIPP IKVIIPKFSL SDWNSVLAMI GEKVFPLGGV
RKLFTMDGHL LDDSKNLQDN YFYVAAGLET FKSIPYWKSS WVPSEVQQRF GGNDKYTQTK
KRVESKVKEP LQNDSVPPRS QDSVYYAKEK KQMDTELLVQ SGAEGDVYKA QTPAKEAQEA
LEVKEDPEVK VEVPVDQAPA EIVKEIDEIG DSSPGLKSGM HIPASFM
