ID   DCD3B_DICDI             Reviewed;         285 AA.
AC   Q55DQ0;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative alkaline ceramidase dcd3B;
DE            EC=3.5.1.-;
GN   Name=dcd3B; ORFNames=DDB_G0269574;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alkaline ceramidase family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72137.1; -; Genomic_DNA.
DR   RefSeq; XP_646081.1; XM_640989.1.
DR   AlphaFoldDB; Q55DQ0; -.
DR   SMR; Q55DQ0; -.
DR   STRING; 44689.DDB0232053; -.
DR   PaxDb; Q55DQ0; -.
DR   EnsemblProtists; EAL72137; EAL72137; DDB_G0269574.
DR   GeneID; 8617031; -.
DR   KEGG; ddi:DDB_G0269574; -.
DR   dictyBase; DDB_G0269574; dcd3B.
DR   eggNOG; KOG2329; Eukaryota.
DR   HOGENOM; CLU_063293_3_0_1; -.
DR   InParanoid; Q55DQ0; -.
DR   OMA; GSMCWLS; -.
DR   PhylomeDB; Q55DQ0; -.
DR   PRO; PR:Q55DQ0; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0070774; F:phytoceramidase activity; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:InterPro.
DR   InterPro; IPR008901; ACER.
DR   PANTHER; PTHR46187; PTHR46187; 1.
DR   Pfam; PF05875; Ceramidase; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..285
FT                   /note="Putative alkaline ceramidase dcd3B"
FT                   /id="PRO_0000390657"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  32948 MW;  6DA65E09A6287235 CRC64;
     MENEINYWGV PDSPIDWCEE NYIISKYICE FYNTFSSFII TAFGVYGIFL MMSASSRDQA
     LFQHVKIMKE LKIRQKVLFS YLSLAIVGVG SAFYHATLLY KNQLFDEFPM MLTASMFVYC
     ILTIDPVDEK NDTATYKLMR RFLPYILSLY VIVVAITITI IRDSPIILQS SFGLLIFSNV
     FLSYMYTSRC LKTPVMESNP KKFLYLCIAS MGIAYISWLT ERKLCNNGYV IPGVQLHAVW
     HALTGLAGFY YIQFFITSCL EKHGYKTKLN WNYGIASVRG FIKSY