ACTP_SHIFL
ID ACTP_SHIFL Reviewed; 549 AA.
AC Q83P94; Q7BZL0;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Cation/acetate symporter ActP;
DE AltName: Full=Acetate permease;
DE AltName: Full=Acetate transporter ActP;
GN Name=actP; OrderedLocusNames=SF4127, S3594;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Transports acetate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005674; AAN45551.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18639.1; -; Genomic_DNA.
DR RefSeq; NP_709844.1; NC_004337.2.
DR RefSeq; WP_000832580.1; NZ_WPGW01000075.1.
DR AlphaFoldDB; Q83P94; -.
DR SMR; Q83P94; -.
DR STRING; 198214.SF4127; -.
DR EnsemblBacteria; AAN45551; AAN45551; SF4127.
DR EnsemblBacteria; AAP18639; AAP18639; S3594.
DR GeneID; 1027384; -.
DR GeneID; 58390019; -.
DR KEGG; sfl:SF4127; -.
DR KEGG; sfx:S3594; -.
DR PATRIC; fig|198214.7.peg.4869; -.
DR HOGENOM; CLU_018808_8_3_6; -.
DR OMA; GTTWVQM; -.
DR OrthoDB; 278483at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015123; F:acetate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043879; F:glycolate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR HAMAP; MF_01426; Acet_symport_ActP; 1.
DR InterPro; IPR014083; Cation/Ac_symporter_ActP.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR TIGRFAMs; TIGR02711; symport_actP; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..549
FT /note="Cation/acetate symporter ActP"
FT /id="PRO_0000105415"
FT TOPO_DOM 1..32
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..102
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..182
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..260
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..349
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..427
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 485..493
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 517..549
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 549 AA; 59163 MW; FB8189DC4BDE4EFA CRC64;
MKRVLTALAA TLPFAANAAD AISGAVERQP TNWQAIIMFL IFVVFTLGIT YWASKRVRSR
SDYYTAGGNI TGFQNGLAIA GDYMSAASFL GISALVFTSG YDGLIYSLGF LVGWPIILFL
IAERLRNLGR YTSADVASYR LKQGPIRILS ACGSLVVVAL YLIAQMVGAG KLIELLFGLN
YHIAVVLVGV LMMMYVLFGG MLATTWVQII KAVLLLFGAS FMAFMVMKHV GFSFNNLFSE
AMAVHPKGVD IMKPGGLVKD PISALSLGLG LMFGTAGLPH ILMRFFTVSD AREARKSVFY
ATGFMGYFYI LTFIIGFGAI MLVGANPEYK DAAGHLIGGN NMAAVHLANA VGGNLFLGFI
SAVAFATILA VVADLTLAGA SAVSHDLYAN VFKKGATERE ELRVSKITVL ILGVIAIILG
VLFENQNIAF MVGLAFAIAA SCNFPIILLS MYWSKLTTRG AMLGGWLGLI TAVVLMILGP
TIWVQILGHE KAIFPYEYPA LFSISVAFLG IWFFSATDNS AEGARERELF RAQFIRSQTG
FGVEQGRAH
