DCDC1_HUMAN
ID DCDC1_HUMAN Reviewed; 1783 AA.
AC M0R2J8; A6PVL6; B1AL47; B7WNX6; P59894; Q6ZRR9; Q6ZU04;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Doublecortin domain-containing protein 1 {ECO:0000305};
DE AltName: Full=Doublecortin domain-containing 5 protein {ECO:0000303|PubMed:22159412};
GN Name=DCDC1 {ECO:0000312|HGNC:HGNC:20625};
GN Synonyms=DCDC5 {ECO:0000303|PubMed:22159412}, KIAA1493;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=12820024; DOI=10.1007/s10038-003-0033-3;
RA Zeng L., Gu S., Li Y., Zhao E., Xu J., Ye X., Wu Q., Wang L., Xie Y.,
RA Mao Y.;
RT "Identification of a novel human doublecortin-domain-containing gene
RT (DCDC1) expressed mainly in testis.";
RL J. Hum. Genet. 48:393-396(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, MICROTUBULE-BINDING, AND INTERACTION WITH
RP DYNEIN INTERMEDIATE CHAIN; TUBULIN; RAB8A; RAB3IP; NUDC; PAFAH1B1 AND
RP DCTN1.
RX PubMed=22159412; DOI=10.1242/jcs.085407;
RA Kaplan A., Reiner O.;
RT "Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody
RT during cytokinesis by the doublecortin domain-containing 5 protein.";
RL J. Cell Sci. 124:3989-4000(2011).
CC -!- FUNCTION: Microtubule-binding protein which plays an important role in
CC mediating dynein-dependent transport of RAB8A-positive vesicles to the
CC midbody during cytokinesis (PubMed:22159412).
CC {ECO:0000269|PubMed:22159412}.
CC -!- SUBUNIT: Interacts with dynein intermediate chain, tubulin, RAB8A,
CC RAB3IP, NUDC, PAFAH1B1 and DCTN1 (PubMed:22159412).
CC {ECO:0000269|PubMed:22159412}.
CC -!- SUBCELLULAR LOCATION: Midbody, Midbody ring
CC {ECO:0000269|PubMed:22159412}. Midbody {ECO:0000269|PubMed:22159412}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22159412}.
CC Note=Associated with microtubules, in particular, with stabilized
CC microtubules of the mitotic spindle during metaphase and with midbody
CC microtubules during cytokinesis. {ECO:0000269|PubMed:22159412}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=M0R2J8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=M0R2J8-2; Sequence=VSP_060022, VSP_060023;
CC Name=3;
CC IsoId=M0R2J8-3; Sequence=VSP_060024, VSP_060025;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence and several conflicts. Sequence of unknown origin in the N-terminal part of the CDS.; Evidence={ECO:0000305};
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DR EMBL; AY247970; AAP75563.1; -; mRNA.
DR EMBL; AK126066; BAC86423.2; -; mRNA.
DR EMBL; AK128035; BAC87240.1; ALT_SEQ; mRNA.
DR EMBL; AL133296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL162614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS7872.1; -. [M0R2J8-3]
DR RefSeq; NP_861523.2; NM_181807.3. [M0R2J8-3]
DR AlphaFoldDB; M0R2J8; -.
DR BioGRID; 131112; 8.
DR IntAct; M0R2J8; 1.
DR STRING; 9606.ENSP00000385936; -.
DR iPTMnet; M0R2J8; -.
DR PhosphoSitePlus; M0R2J8; -.
DR BioMuta; DCDC1; -.
DR BioMuta; HGNC:24799; -.
DR DMDM; 190359182; -.
DR jPOST; M0R2J8; -.
DR MassIVE; M0R2J8; -.
DR PeptideAtlas; M0R2J8; -.
DR PRIDE; M0R2J8; -.
DR ProteomicsDB; 57166; -.
DR ProteomicsDB; 6281; -.
DR ProteomicsDB; 68160; -.
DR Antibodypedia; 48955; 59 antibodies from 8 providers.
DR DNASU; 341019; -.
DR Ensembl; ENST00000342355.8; ENSP00000343496.4; ENSG00000170959.15. [M0R2J8-2]
DR Ensembl; ENST00000452803.1; ENSP00000389792.1; ENSG00000170959.15. [M0R2J8-3]
DR Ensembl; ENST00000597505.5; ENSP00000472625.1; ENSG00000170959.15. [M0R2J8-1]
DR GeneID; 341019; -.
DR KEGG; hsa:341019; -.
DR UCSC; uc058aah.1; human. [M0R2J8-1]
DR CTD; 341019; -.
DR DisGeNET; 341019; -.
DR GeneCards; DCDC1; -.
DR HGNC; HGNC:20625; DCDC1.
DR HPA; ENSG00000170959; Tissue enhanced (choroid).
DR MIM; 608062; gene.
DR neXtProt; NX_M0R2J8; -.
DR OpenTargets; ENSG00000170959; -.
DR PharmGKB; PA134970075; -.
DR VEuPathDB; HostDB:ENSG00000170959; -.
DR eggNOG; ENOG502QW8Q; Eukaryota.
DR GeneTree; ENSGT00940000163628; -.
DR HOGENOM; CLU_067120_0_1_1; -.
DR OMA; TNNFCLI; -.
DR PhylomeDB; M0R2J8; -.
DR TreeFam; TF329467; -.
DR PathwayCommons; M0R2J8; -.
DR SignaLink; M0R2J8; -.
DR BioGRID-ORCS; 341019; 15 hits in 1073 CRISPR screens.
DR ChiTaRS; DCDC1; human.
DR GenomeRNAi; 341019; -.
DR PRO; PR:M0R2J8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000170959; Expressed in oviduct epithelium and 106 other tissues.
DR ExpressionAtlas; M0R2J8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0090543; C:Flemming body; IDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR GO; GO:0072686; C:mitotic spindle; IDA:UniProtKB.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1902412; P:regulation of mitotic cytokinesis; IMP:UniProtKB.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 3.10.20.230; -; 2.
DR InterPro; IPR043188; DCDC1.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR46302; PTHR46302; 3.
DR SMART; SM00537; DCX; 3.
DR SUPFAM; SSF50370; SSF50370; 2.
DR SUPFAM; SSF89837; SSF89837; 5.
DR PROSITE; PS50309; DC; 2.
DR PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cytoplasm; Cytoskeleton;
KW Lectin; Microtubule; Mitosis; Reference proteome; Repeat.
FT CHAIN 1..1783
FT /note="Doublecortin domain-containing protein 1"
FT /id="PRO_0000446088"
FT DOMAIN 168..252
FT /note="Doublecortin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 702..800
FT /note="Ricin B-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT DOMAIN 925..1015
FT /note="Doublecortin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 1151..1266
FT /note="Ricin B-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 93..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 252..270
FT /note="DHLLLIKKVTWTMNGLMLP -> GFRYLYNKNESKFTSQIFL (in
FT isoform 2)"
FT /id="VSP_060022"
FT VAR_SEQ 271..1783
FT /note="Missing (in isoform 2)"
FT /id="VSP_060023"
FT VAR_SEQ 352..354
FT /note="VPL -> GKH (in isoform 3)"
FT /id="VSP_060024"
FT VAR_SEQ 355..1783
FT /note="Missing (in isoform 3)"
FT /id="VSP_060025"
FT VARIANT 7
FT /note="E -> G (in dbSNP:rs11031357)"
FT /id="VAR_037284"
FT VARIANT 83
FT /note="V -> M (in dbSNP:rs2761591)"
FT /id="VAR_033767"
FT CONFLICT 192
FT /note="V -> A (in Ref. 1; AAP75563)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1783 AA; 200591 MW; B4EC8D37407E6A92 CRC64;
MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL NDLPREFMSS
QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH QTASDHSHDE ISDLDSYKSN
SKNNSCSISA SKRNRPVSAP VGQLRVAEFS SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK
NGSRTVFARV TVPTITLLLE ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG
EPFLNPFKKI KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF
KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS KVPLLEKCLQ
NSITPLRGLL WVSKGEGFSP SGAKMYIQGV LLALYQRLKS AKKYYKQLNL VMNEQKEKIT
EKVILSMTAK EHHKEQEEVS RLIDELQTAI KSNIGHLCKL GPQLQAEQEQ FSSYVYQHIK
SLPANTLVPG GLQLKVFENG KNTGEISVGI SKKDLGSDSP IQTDHMMERL LLKIHQRLQG
SSINPPGLNY SSMRLFDENG QEIKNPLSLK NEQKIWVSYG RAYRSPLNLA LGLTFDRVSA
FARGDIMVAY KTFLDPNAVL LPGCGNWEVC EGFPINFNCT SQQIPDQFEK VDLENHFLQN
KVDPNIVLHA SVSIGKWSFS GSEASSRSQI APSILWPVAS VWLITKTGMI LSRAITQGCL
AIGHPIRVKA AEGTSLEGYK LILQKRHSGD DSQKWVFGTD GCIYSKAYPQ FVLTYLEELN
AQVDVTQTEY HIHHGAWTTA HQEHGRNLAE EVLQESASNL GLKQLPEPSD THLMPEGSLE
ETGELTVALV RKLEEKHPKA SAQRWAIKHE GTSKPGQWKH SRVENPLWNK LTYMWPVLPS
GQLNEEFDWP IQGLLVPSSP PMKKPICKTT EPYAPVRLRV LQNGEKNKNR SVTILGPDIS
PGRKTQCTEI LNLPSAARRL YNEKGKEIFA LKDLQRDELV YVSCGELWIN PDLSIAQQKK
QIFLRNLESD IAKIQIFCST HKIEALVLEV QSDIVSGSKL AVHKPVAIFG EEKQVTEPEE
KQMQEDPLTT ENASSEILDS HVRAHLRMKA CHTLPRYAWQ ETSHDFDEDD SLPKKTEKGL
FENVEPQKKH SCSPKHSKLH KHCHQQFEYR DGQIISHAAP QLVLGVQGPN LRSGMEVVLV
EKKSDGSHQR WIHQEDSRTF HLVSNPDLVL AVSMTKTRNE VCGYPVIVQK YKPYNNGAAN
QKWHYMKNIK ALVAFHSTAL DKEITSANYA GVCTSSVIKE ENIDQPGYCY LSPDGKRKTM
LCLACGQSMR TEKGLKQLLP GVPFLCISGT KTQKPFLQGP FKVISVAEVD LSCDKAEKTL
SYYQARLLSL RMKTCTQAAS HSGMAATHQK AVKIIAYKNG DGYRNGKLIV AGTFPMLLTE
CTEQLGLARA ASKVYTKDGT PIFTLRDLVL WALDESFLQR DSEKQKQDAA PVGKEQIIVE
KNPRMKVKNR LFAKSVTSDS LDGIDKSLLT LILRNPIAIW VSCGEPFLPP NALQKAEKLE
KQNWLKKDRI LADLDTMRHK MRQLKGRRVA ACQPATMVPT KSPVQPVVVE GGWTEQTQQE
IKLMELIRHT EAHLSEIQEM ESKINFPIAT KRIAVKPSNL YKQPNTKRVW IYLNGGRPED
GTYAWGKTIS ELLQDCSSRL KMTHPARALY TPSGEPIQSW DDIERDMVIC VSMGHGFKTP
KELKQLMEIR ANYARIRRQQ GPQATDIVVS PSTKLLSLAH LHN
