ID   ACTR_RHIME              Reviewed;         194 AA.
AC   P0C5S3; Q52913;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Acid tolerance regulatory protein ActR;
GN   Name=actR; OrderedLocusNames=R00065; ORFNames=SMc02584;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system ActS/ActR
CC       acting in acid tolerance. These data implicate that a two-component
CC       sensor may be involved in pH sensing and/or response (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated by ActS. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL591688; CAC41452.1; -; Genomic_DNA.
DR   RefSeq; NP_384171.1; NC_003047.1.
DR   RefSeq; WP_010968328.1; NC_003047.1.
DR   AlphaFoldDB; P0C5S3; -.
DR   SMR; P0C5S3; -.
DR   STRING; 266834.SMc02584; -.
DR   EnsemblBacteria; CAC41452; CAC41452; SMc02584.
DR   GeneID; 61601540; -.
DR   KEGG; sme:SMc02584; -.
DR   PATRIC; fig|266834.11.peg.1419; -.
DR   eggNOG; COG4567; Bacteria.
DR   HOGENOM; CLU_000445_69_6_5; -.
DR   OMA; RRLEWEH; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..194
FT                   /note="Acid tolerance regulatory protein ActR"
FT                   /id="PRO_0000080992"
FT   DOMAIN          24..138
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         73
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   194 AA;  21513 MW;  4C6B8B00649419C0 CRC64;
     MIEKSMPAQN THAADADLIG PDKSLLIVDD DTAFLRRLAR AMEARGFAVE IAESVAEGIA
     KAKTRPPKHA VIDLRLSDGS GLDVIEAIRG RRDDTRMIVL TGYGNIATAV NAVKLGALDY
     LAKPADADDI LAALIQRPGE RVEPPENPMS ADRVRWEHIQ RVYEMCERNV SETARRLNMH
     RRTLQRILAK RAPK