ID   ACTR_SINMW              Reviewed;         194 AA.
AC   A6UEL7; Q52913;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Acid tolerance regulatory protein ActR;
GN   Name=actR; OrderedLocusNames=Smed_3273;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8757734; DOI=10.1099/13500872-142-7-1693;
RA   Tiwari R.P., Reeve W.G., Dilworth M.J., Glenn A.R.;
RT   "Acid tolerance in Rhizobium meliloti strain WSM419 involves a two-
RT   component sensor-regulator system.";
RL   Microbiology 142:1693-1704(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system ActS/ActR
CC       acting in acid tolerance. These data implicate that a two-component
CC       sensor may be involved in pH sensing and/or response.
CC   -!- PTM: Phosphorylated by ActS. {ECO:0000305}.
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DR   EMBL; L39938; AAB38421.2; -; Genomic_DNA.
DR   EMBL; CP000738; ABR62097.1; -; Genomic_DNA.
DR   RefSeq; WP_012067478.1; NC_009636.1.
DR   RefSeq; YP_001328932.1; NC_009636.1.
DR   AlphaFoldDB; A6UEL7; -.
DR   SMR; A6UEL7; -.
DR   STRING; 366394.Smed_3273; -.
DR   EnsemblBacteria; ABR62097; ABR62097; Smed_3273.
DR   GeneID; 61610855; -.
DR   KEGG; smd:Smed_3273; -.
DR   PATRIC; fig|366394.8.peg.6514; -.
DR   eggNOG; COG4567; Bacteria.
DR   HOGENOM; CLU_000445_69_6_5; -.
DR   OMA; RRLEWEH; -.
DR   OrthoDB; 930905at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..194
FT                   /note="Acid tolerance regulatory protein ActR"
FT                   /id="PRO_0000310444"
FT   DOMAIN          24..138
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         73
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   194 AA;  21421 MW;  9BD60917F815CB4D CRC64;
     MIEKSTPAPI THAADADLIG PDKSLLIVDD DTAFLRRLAR AMEARGFAVE IAESVAEGIA
     KAKTRPPKHA VIDLRLGDGS GLDVIEAIRG RRDDTRMIVL TGYGNIATAV NAVKLGALDY
     LAKPADADDI LAALIQRPGE RVEPPENPMS ADRVRWEHIQ RVYEMCERNV SETARRLNMH
     RRTLQRILAK RAPK