ID   ACTS_PLEWA              Reviewed;         125 AA.
AC   P10994;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Actin, alpha skeletal muscle;
DE   Flags: Fragment;
OS   Pleurodeles waltl (Iberian ribbed newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Pleurodeles.
OX   NCBI_TaxID=8319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3453122; DOI=10.1016/0022-2836(87)90229-4;
RA   Khrestchatisky M., Fontes M.;
RT   "There is an alpha-actin skeletal muscle-specific gene in a salamander
RT   (Pleurodeles waltlii).";
RL   J. Mol. Biol. 193:409-412(1987).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBUNIT: Polymerization of globular actin (G-actin) leads to a
CC       structural filament (F-actin) in the form of a two-stranded helix. Each
CC       actin can bind to 4 others.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- PTM: Methylated at His-75 by SETD3. {ECO:0000250|UniProtKB:P68133}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; X05106; CAA28753.1; -; mRNA.
DR   PIR; A26337; A26337.
DR   AlphaFoldDB; P10994; -.
DR   SMR; P10994; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Muscle protein; Nucleotide-binding.
FT   CHAIN           <1..125
FT                   /note="Actin, alpha skeletal muscle"
FT                   /id="PRO_0000089055"
FT   NON_TER         1
SQ   SEQUENCE   125 AA;  14102 MW;  4012AD024CD2AC89 CRC64;
     GNERFRCPET LFQPSFIGME SAGIHETTYN SIMKCDIDIR KDLYANNVMS GGTTMYPGIA
     DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWITKQ EYDEAGPSIV
     HRKCF