ID   ACTT1_MACFA             Reviewed;         375 AA.
AC   Q4R821;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Actin-related protein T1;
GN   Name=ACTRT1; ORFNames=QtsA-13725;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates the Hedgehog (SHH) signaling. Binds to
CC       the promoter of the SHH signaling mediator, GLI1, and inhibits its
CC       expression. {ECO:0000250|UniProtKB:Q8TDG2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q8TDG2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8TDG2}. Nucleus {ECO:0000250|UniProtKB:Q8TDG2}.
CC       Note=Both detected in the nucleus and cytoplasm, localizes to the
CC       nucleus where it binds chromatin upon stimulation of the Hedgehog
CC       pathway. {ECO:0000250|UniProtKB:Q8TDG2}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; AB168640; BAE00751.1; -; mRNA.
DR   RefSeq; NP_001272021.1; NM_001285092.1.
DR   AlphaFoldDB; Q4R821; -.
DR   SMR; Q4R821; -.
DR   STRING; 9541.XP_005594587.1; -.
DR   GeneID; 101865687; -.
DR   CTD; 139741; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   OrthoDB; 708610at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030139; Arp-T1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF153; PTHR11937:SF153; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..375
FT                   /note="Actin-related protein T1"
FT                   /id="PRO_0000255657"
SQ   SEQUENCE   375 AA;  41699 MW;  50321EC6FA2187BB CRC64;
     MFNPHVLDVP AVIFDNGSGL CKAGVSGEIG PRHVINSVLG HRKFNMPSAR LNQYFVGQEA
     LYKFDALHLH YPIKRGLVTG WDDMEKLWKH LFEWELGVKP SQQPVLMTEP SLNPREIREK
     LAEMMFENFS VPGFYLSNHA VAALYASACV TGLVVDSGDG VTCAVPIFEG YSLPHAVTKL
     YTAGRDITEH LTQLLFANGF NFPCILNKAV ANNIKEKLCY IALEPEKELR KSRGEVLGAY
     RLPDGHVIHF GDELYQVPEV LFAPDQLGIH SPGLSKMVSS SIMKCDTDIQ NKLYAEIVLS
     GGTTLFPGLE ERLMKEVEQL ASKGTPIKIT ASPDRCFSAW IGASIMTSMS SFKQMWVTSA
     DFKEYGTSVV QRRCF