ACTT1_MOUSE
ID ACTT1_MOUSE Reviewed; 376 AA.
AC Q9D9J3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Actin-related protein T1;
GN Name=Actrt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negatively regulates the Hedgehog (SHH) signaling. Binds to
CC the promoter of the SHH signaling mediator, GLI1, and inhibits its
CC expression. {ECO:0000250|UniProtKB:Q8TDG2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q8TDG2}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8TDG2}. Nucleus {ECO:0000250|UniProtKB:Q8TDG2}.
CC Note=Both detected in the nucleus and cytoplasm, localizes to the
CC nucleus where it binds chromatin upon stimulation of the Hedgehog
CC pathway. {ECO:0000250|UniProtKB:Q8TDG2}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK006855; BAB24765.1; -; mRNA.
DR EMBL; BC116431; AAI16432.1; -; mRNA.
DR EMBL; BC116432; AAI16433.1; -; mRNA.
DR CCDS; CCDS30102.1; -.
DR RefSeq; NP_082790.1; NM_028514.3.
DR AlphaFoldDB; Q9D9J3; -.
DR SMR; Q9D9J3; -.
DR STRING; 10090.ENSMUSP00000062570; -.
DR PhosphoSitePlus; Q9D9J3; -.
DR PaxDb; Q9D9J3; -.
DR PRIDE; Q9D9J3; -.
DR ProteomicsDB; 285856; -.
DR Antibodypedia; 511; 119 antibodies from 22 providers.
DR DNASU; 73360; -.
DR Ensembl; ENSMUST00000059466; ENSMUSP00000062570; ENSMUSG00000046615.
DR GeneID; 73360; -.
DR KEGG; mmu:73360; -.
DR UCSC; uc009tbj.1; mouse.
DR CTD; 139741; -.
DR MGI; MGI:1920610; Actrt1.
DR VEuPathDB; HostDB:ENSMUSG00000046615; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000162451; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q9D9J3; -.
DR OMA; ITEHLIR; -.
DR OrthoDB; 708610at2759; -.
DR PhylomeDB; Q9D9J3; -.
DR TreeFam; TF354237; -.
DR BioGRID-ORCS; 73360; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9D9J3; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D9J3; protein.
DR Bgee; ENSMUSG00000046615; Expressed in spermatid and 18 other tissues.
DR Genevisible; Q9D9J3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR030139; Arp-T1.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF153; PTHR11937:SF153; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..376
FT /note="Actin-related protein T1"
FT /id="PRO_0000255658"
SQ SEQUENCE 376 AA; 42216 MW; 9401FD390644F655 CRC64;
MLDPARLDNP AVIFDNGSGL CKVGISGEIE PRHVINSVVG HPKFNIPSAR SNRKRYFVGE
EAQCMYDGLY LHYPIERGLV TRWDDMEKLW KDLFEWELGV KPNEQPVFMT EPSLNPQETR
EKTTEIMFEK FNVPALYLCN HAVGALCASA CITGLVLDSG DGVTCTVPVY EGYSLPHAIT
KLYVAGRDIT EHLTRLLLAK GYTFPCILNK AVVDDIKEKL CTVSLGYKDT EKNCQQFLRK
YTLPDGNTIQ MSDHLCQVPE VLFTPDHLGI HDLGISKMVC NSIMNCDTDI QENLFAEIVL
SGGTTMFPGL QDRLLKELED LAFEGTPIKI TASSDRCYSA WIGGSVMTSM TTFKQMWVTA
EDFKEYGAFV VQRKCF
