ID   ACTT1_RAT               Reviewed;         376 AA.
AC   Q5XIK1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Actin-related protein T1;
GN   Name=Actrt1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Negatively regulates the Hedgehog (SHH) signaling. Binds to
CC       the promoter of the SHH signaling mediator, GLI1, and inhibits its
CC       expression. {ECO:0000250|UniProtKB:Q8TDG2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q8TDG2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8TDG2}. Nucleus {ECO:0000250|UniProtKB:Q8TDG2}.
CC       Note=Both detected in the nucleus and cytoplasm, localizes to the
CC       nucleus where it binds chromatin upon stimulation of the Hedgehog
CC       pathway. {ECO:0000250|UniProtKB:Q8TDG2}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC083679; AAH83679.1; -; mRNA.
DR   RefSeq; NP_001013983.1; NM_001013961.1.
DR   AlphaFoldDB; Q5XIK1; -.
DR   SMR; Q5XIK1; -.
DR   STRING; 10116.ENSRNOP00000053759; -.
DR   PaxDb; Q5XIK1; -.
DR   Ensembl; ENSRNOT00000004591; ENSRNOP00000053759; ENSRNOG00000003456.
DR   GeneID; 302796; -.
DR   KEGG; rno:302796; -.
DR   UCSC; RGD:1359559; rat.
DR   CTD; 139741; -.
DR   RGD; 1359559; Actrt1.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000162451; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q5XIK1; -.
DR   OMA; CMAGRDI; -.
DR   OrthoDB; 708610at2759; -.
DR   PhylomeDB; Q5XIK1; -.
DR   TreeFam; TF354237; -.
DR   PRO; PR:Q5XIK1; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000003456; Expressed in testis.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030139; Arp-T1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF153; PTHR11937:SF153; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..376
FT                   /note="Actin-related protein T1"
FT                   /id="PRO_0000255659"
SQ   SEQUENCE   376 AA;  42195 MW;  0604FDD477578550 CRC64;
     MLNTARLDNP AVIFDNGSGL CKVGISGEIV PRHVINSVVG HPKFNIPSAR SNRKRYFVGE
     EAQCMYDGLY LHYPIERGLV TRWDDMEKLW KDLFEWELGV KPNEQPVFMT EPSLNPRETR
     EKTTEIMFEK FNVPALYLCN HAVGALCASA CITGLVLDSG DGVTCTVPIY EGYSLPRAIT
     KLYVAGRDIT EHLTRLLLAK GYTFPCILNK AVVDDIKEKL CTVSWGSKDS EKCYQRSLSE
     YKLPDGNTIQ MSDHLCQVPE VLFTPEHLGI HDLGISKMVC NSIMKCDTDI QENLFAEIVL
     SGGTTLFPGL QDRLLKELEV LAFEGTPIKI TASPDRCYSA WIGGSVMTSL TTFKQMWVTA
     EDFKEYGAFV VQRKCF